Carbon Dots Based Nanoscale Covalent Organic Frameworks for Photodynamic Therapy
Carbon Dots Based Nanoscale Covalent Organic Frameworks for Photodynamic Therapy
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用于光动力治疗的基于碳点的纳米级共价有机框架
DOI：
10.1002/adfm.202004680
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发表时间：
2020-09-06
影响因子：
19
通讯作者：
Xie, Zhigang
中科院分区：
文献类型：
--
作者：
Chen, Shuang;Sun, Tingting;Xie, Zhigang
共价有机骨架（COFs）因其广泛的应用而备受关注，但开发具有生物医学功能的COFs仍然是一个巨大的挑战。大多数COF纯粹由有机分子构建，迄今为止还没有开发基于碳点（CD）的COF。本论文以二胺分子对苯二胺和BODIPY为模型单体，分别与含环糊精的环糊精反应，构建了纳米级的COF，分别命名为CCOF-1和CCOF-2。经聚乙二醇（PEG）改性后，CCOF-1@PEG和CCOF-2@PEG在水介质中稳定且分散性良好。CCOF-2@PEG具有良好的生理稳定性、良好的生物相容性和较强的活性氧产生能力，使其成为一种优良的光动力学治疗（PDT）剂用于肿瘤治疗。体外和体内实验表明，PDT对抑制细胞增殖和肿瘤生长具有很高的治疗效率。这项工作展示了一种新的战略，制造功能COF为基础的平台，用于生物医学应用。
Covalent organic frameworks (COFs) have attracted much attention for various applications, while developing COFs with biomedical functions remains a big challenge. Most COFs are built purely from organic molecules, no carbon dots (CDs)-based COFs have been exploited to date. In this work, diamine molecules p-phenylenediamine and BODIPY are selected as model monomers to react with aldehyde-containing CDs and construct nanoscale COFs, named CCOF-1 and CCOF-2, respectively. After the modification with poly(ethylene glycol) (PEG), the formed CCOF-1@PEG and CCOF-2@PEG are stable and well-dispersible in aqueous media. The merits of CCOF-2@PEG containing favorable physiological stability, good biocompatibility, and strong reactive oxygen species generation ability enable it to act as an excellent photodynamic therapy (PDT) agent for tumor treatment. The high PDT therapeutic efficiency for inhibiting cell proliferation and tumor growth was well shown by in vitro and in vivo experiments. This work demonstrates a new strategy for fabricating functional COF-based platforms for biomedical applications.