Distribution of neurons expressing tyrosine hydroxylase in the human cerebral cortex
Distribution of neurons expressing tyrosine hydroxylase in the human cerebral cortex
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DOI：
10.1111/j.1469-7580.2007.00760.x
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发表时间：
2007-08-01
影响因子：
2.4
通讯作者：
DeFelipe, Javier
中科院分区：
文献类型：
--
作者：
Benavides-Piccione, Ruth;DeFelipe, Javier
自从卡哈尔首次详细描述不同类型的皮质中间神经元以来，这些细胞的形态、生理学和神经化学特性的巨大差异已经变得显而易见。然而，目前仍不清楚是否所有类型的中间神经元都存在于所有皮质区域和物种中。在这里，我们重点关注酪氨酸羟化酶（TH）免疫反应性皮质中间神经元，虽然仅存在于某些物种中，但在人类新皮质中特别丰富。我们认为，这种类型的中间神经元在人类新皮质中比迄今为止检查的任何其他物种中更广泛，因此，它可能涉及更多种类的皮质回路。此外，这些中间神经元还存在显着的区域差异。这些差异进一步强调了皮层区域和物种之间微电路设计的可变性，它们可能反映了皮层电路对特定功能的进化适应。
Since the very first detailed description of the different types of cortical interneurons by Cajal, the tremendous variation in the morphology, physiology and neurochemical properties of these cells has become apparent. However, it still remains unclear whether all types of interneurons are present in all cortical areas and species. Here we have focused on tyrosine hydroxylase (TH)-immunoreactive cortical interneurons, which although only present in certain species, are particularly abundant in the human neocortex. We argue that this type of interneuron is more widespread in the human neocortex than in any other species examined so far and that, therefore, it is probably involved in a larger variety of cortical circuits. In addition, notable regional variation can be seen in relation to these interneurons. These differences further emphasize the variability in the design of microcircuits between cortical areas and species, and they probably reflect an evolutionary adaptation of cortical circuits to particular functions.