Input source and strength influences overall firing phase of model hippocampal CA1 pyramidal cells during theta: Relevance to REM sleep reactivation and memory consolidation
Input source and strength influences overall firing phase of model hippocampal CA1 pyramidal cells during theta: Relevance to REM sleep reactivation and memory consolidation
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DOI：
10.1002/hipo.20143
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发表时间：
2006-01-01
期刊：
影响因子：
3.5
通讯作者：
Poe, GR
中科院分区：
文献类型：
--
作者：
Booth, V;Poe, GR
在使用真实模型CA 1锥体细胞的模拟研究中，我们解释了在逐渐熟悉环境的几天内，海马CA 1位置细胞在快速眼动（REM）睡眠再激活期间平均放电相位从θ周期峰到θ周期谷的转变（Brain Res 855：176-180）。当刺激出现在近端和远端树突位置时，细胞近端和远端树突区域之间的θ驱动相位和振幅的变化调制了θ相位的发射。刺激近端树突状位点（近端至100 μ m，从索马）调用发射与一个显着的相位偏好在去极化θ峰，而远端刺激（> 290 μ m，从索马）调用发射超极化θ谷。与输入位置相关的相位偏好取决于活跃的树枝状电导、输入位点之间足够的电紧张分离以及细胞中θ诱导的阈下膜电位振荡。模拟结果预测，在REM睡眠期间的平均θ相的移动细胞再激活可能会发生通过增强远端树突（颞-氨）突触和去增强近端树突（谢弗侧支）突触在熟悉的过程中。(c)2006威利-利斯公司
In simulation studies using a realistic model CA1 pyramidal cell, we accounted for the shift in mean firing phase from theta cycle peaks to theta cycle troughs during rapid-eye movement (REM) sleep reactivation of hippocampal CA1 place cells over several days of growing familiarization with an environment (Brain Res 855:176-180). Changes in the theta drive phase and amplitude between proximal and distal dendritic regions of the cell modulated the theta phase of firing when stimuli were presented at proximal and distal dendritic locations. Stimuli at proximal dendritic sites (proximal to 100 pm from the soma) invoked firing with a significant phase preference at the depolarizing theta peaks, while distal stimuli ( > 290 mu m from the soma) invoked firing at hyperpolarizing theta troughs. The input location-related phase preference depended on active dendritic conductances, a sufficient electrotonic separation between input sites and theta-induced subthreshold membrane potential oscillations in the cell. The simulation results predict that the shift in mean theta phase during REM sleep cellular reactivation could occur through potentiation of distal dendritic (temporo-ammonic) synapses and depotentiation of proximal dendritic (Schaffer collateral) synapses over the course of familiarization. (c) 2006 Wiley-Liss, Inc.