Endosomes: A legitimate platform for the signaling train
Endosomes: A legitimate platform for the signaling train
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DOI：
10.1073/pnas.0906541106
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发表时间：
2009-10-20
影响因子：
11.1
通讯作者：
Bunnett, Nigel W.
中科院分区：
文献类型：
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作者：
Murphy, Jane E.;Padilla, Benjamin E.;Bunnett, Nigel W.
虽然长期以来被认为是细胞表面受体降解或再循环的管道，但内体系统也是信号转导的重要部位。激活的受体在核内体中积累，某些信号成分仅局限于核内体。受体可以继续传递来自核内体的不同于来自质膜的信号，从而产生不同的生理反应。内体信号在后生动物和植物中广泛存在，它为多种受体家族传递信号，调节包括生长、分化和生存在内的基本过程。内体膜上的受体信号受到控制激动剂可用性、受体与信号机制耦合以及信号成分亚细胞定位的机制的严格调控。靶向在质膜上启动和终止受体信号传导机制的药物是广泛而有效的疾病治疗方法。内体中受体信号的选择性破坏可以通过靶向内体特异性信号通路或通过选择性向内体网络递送药物来实现，这可能为疾病提供新的治疗方法。
Although long regarded as a conduit for the degradation or recycling of cell surface receptors, the endosomal system is also an essential site of signal transduction. Activated receptors accumulate in endosomes, and certain signaling components are exclusively localized to endosomes. Receptors can continue to transmit signals from endosomes that are different from those that arise from the plasma membrane, resulting in distinct physiological responses. Endosomal signaling is widespread in metazoans and plants, where it transmits signals for diverse receptor families that regulate essential processes including growth, differentiation and survival. Receptor signaling at endosomal membranes is tightly regulated by mechanisms that control agonist availability, receptor coupling to signaling machinery, and the subcellular localization of signaling components. Drugs that target mechanisms that initiate and terminate receptor signaling at the plasma membrane are widespread and effective treatments for disease. Selective disruption of receptor signaling in endosomes, which can be accomplished by targeting endosomal-specific signaling pathways or by selective delivery of drugs to the endosomal network, may provide novel therapies for disease.