Usefulness of FDG-PET to diagnose intravascular lymphomatosis presenting as fever of unknown origin
Usefulness of FDG-PET to diagnose intravascular lymphomatosis presenting as fever of unknown origin
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DOI：
10.1002/ajh.20099
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发表时间：
2004-07-01
影响因子：
12.8
通讯作者：
Tamura, J
中科院分区：
文献类型：
--
作者：
Hoshino, A;Kawada, E;Tamura, J
血管内淋巴瘤（IVL）是一种罕见的全身性疾病，以小动脉、静脉和毛细血管腔内淋巴样细胞增生为特征。诊断需要皮肤、肝脏、肺、骨髓、肾脏、脑膜或脑血管活检，但通常只有在疾病进展或死后才进行，因为早期器官受累不明显。我们报告一例IVL表现为不明原因发热（FUO）。在本例中，镓显像和计算机断层扫描（CT）未显示恶性肿瘤的证据，而f -18氟脱氧葡萄糖正电子发射断层扫描（FDG- pet）显示胸骨、左右椎体、肱骨、股骨，尤其是髂骨的FDG摄取增加。经髂骨髓活检诊断。FDG-PET可用于检测IVL合并FUO患者的疾病传播。(C) 2004 Wiley-Liss, Inc。
Intravascular lymphomatosis (IVL) is a rare systemic disease characterized by proliferation of lymphoid cells within the lumina of small arteries, veins, and capillaries. Diagnosis requires skin, liver, lung, bone marrow, renal, meningeal, or brain vessel biopsy but is often made only when the illness has progressed or post mortem because early involvement of organs was not evident. We report a case of IVL presenting as fever of unknown origin (FUO). In this case, gallium scintigraphy and computed tomography (CT) showed no evidence of malignancy, whereas F-18-fluorodeoxyglucose positron emission tomography (FDG-PET) showed increased FDG uptake in the sternum, left and right vertebra, humerus, femur, and especially ilium. The diagnosis was made on iliac bone marrow biopsy examination. FDG-PET was useful for the detection of spread of disease in a patient with IVL suffering from FUO. (C) 2004 Wiley-Liss, Inc.