Bitter correlationship between autoimmune hepatitis and smoking
Bitter correlationship between autoimmune hepatitis and smoking
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DOI：
10.1016/j.mehy.2014.12.006
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发表时间：
2015-02-01
影响因子：
4.7
通讯作者：
Bose, Tanima
中科院分区：
文献类型：
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作者：
Bose, Tanima
香烟烟雾中含有大量有毒、致癌和致突变化学物质、稳定和不稳定的自由基和活性氧（ROS），可引起生物氧化损伤。持续接触这些化学物质会直接或间接对人类健康造成巨大损害。这里提出了一个假设，即发生自身免疫性肝炎 (AIH) 的一个可能解释是由于长年吸烟。为了检验这一假设，我依靠患者的经历，以及对有关吸烟和不同自身免疫性疾病的文献的批判性阅读。在自身免疫性疾病中，类风湿性关节炎（RA）、多发性硬化症（MS）、甲状腺疾病、原发性胆汁性肝硬化（PBC）大多发生在接触烟草的动物中。观察和理论知识强化了吸烟可能是产生自身免疫性肝炎的原因之一的假设。这一假设可能会带来新的诊断类别，以及改变常规吸烟行为的治疗方法。 (c) 2014 Elsevier Ltd. 保留所有权利。
Cigarette smoke contains numerous toxic, carcinogenic and mutagenic chemicals, stable and unstable free radicals and reactive oxygen species (ROS) which cause biological oxidative damage. Continuous exposure to those chemicals leads to immense amount of damage to the human health either directly or indirectly. A hypothesis is advanced here that a possible explanation for developing autoimmune hepatitis (AIH) is due to regular smoking for long years of time. To examine this hypothesis, I relied on an experience of a case of a patient, as well as critical reading of the literature on smoking and different autoimmune disorders. Among the autoimmune diseases, rheumatoid arthritis (RA), multiple sclerosis (MS), thyroid disease, primary biliary cirrhosis (PBC) are reported mostly among tobacco-exposed animals. The observational and theoretical knowledge strengthen the hypothesis that smoking can be one of the causes of generating autoimmune hepatitis. This hypothesis could lead to a new diagnostic category, as well as therapeutic approaches for changing the regular smoking behavior. (c) 2014 Elsevier Ltd. All rights reserved.