Loss of cellular polarity/cohesiveness in the invasive front of papillary thyroid carcinoma and periostin expression
Loss of cellular polarity/cohesiveness in the invasive front of papillary thyroid carcinoma and periostin expression
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DOI：
10.1016/j.canlet.2009.02.043
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发表时间：
2009-08-28
期刊：
影响因子：
9.7
通讯作者：
Zhou, Gengyin
中科院分区：
文献类型：
--
作者：
Bai, Yanhua;Kakudo, Kennichi;Zhou, Gengyin
细胞极性/凝聚性的丧失和Periostin的表达参与了上皮性恶性肿瘤的上皮-间充质转化过程。并对它们在甲状腺乳头状癌中的作用进行了研究。侵袭前沿细胞极性/凝聚性的丧失与肿瘤组织中Periostin的上调密切相关。两者均与甲状腺外侵袭、甲状旁腺功能亢进和淋巴结转移密切相关。我们的结果表明，细胞极性/凝聚性的丧失是预测甲状腺乳头状癌患者预后的有用参数，Periostin可能成为阻断肿瘤侵袭的候选基因。(C)2009爱思唯尔爱尔兰有限公司。保留所有权利。
Loss of cellular polarity/cohesiveness and periostin expression are involved in the epithelial-mesenchymal transition in the epithelial malignancies. Their roles in papillary thyroid carcinoma were studied. There was a significant correlation between the loss of cellular polarity/cohesiveness in the invasive front and the up-regulation of periostin in tumors. Both of them were significantly correlated with extrathyroid invasion, pT and lymph node metastasis. Our results suggest that the loss of cellular polarity/cohesiveness is a useful parameter for predicting prognosis of patients with papillary thyroid carcinoma, and periostin could be a candidate gene for therapeutic targeting for the blockage of tumor invasion. (C) 2009 Elsevier Ireland Ltd. All rights reserved.