2-aryl indole NK1 receptor antagonists:: Optimisation of the 2-aryl ring and the indole nitrogen substituent
2-aryl indole NK1 receptor antagonists:: Optimisation of the 2-aryl ring and the indole nitrogen substituent
复制标题
DOI：
10.1016/s0960-894x(01)00183-4
复制
发表时间：
2001-05-07
影响因子：
2.7
通讯作者：
Swain, CJ
中科院分区：
文献类型：
--
作者：
Dinnell, K;Chicchi, GG;Swain, CJ
合成了新型的2-芳基吲哚HNK(1)受体配体，以钯为中间体的交叉偶联反应为关键步骤。合成了具有较高的HNK(1)受体亲和力和良好的脑渗透性(如9d)的化合物。(C)2001爱思唯尔科学有限公司。保留所有权利。
Novel 2-aryl indole hNK(1) receptor ligands were prepared utilising palladium cross-coupling chemistry of a late intermediate as a key step. Compounds with high hNK(1) receptor binding affinity and good brain penetration (e.g., 9d) were synthesised. (C) 2001 Elsevier Science Ltd. All rights reserved.