Preliminary results of a Japanese nationwide survey of neuroendocrine gastrointestinal tumors
Preliminary results of a Japanese nationwide survey of neuroendocrine gastrointestinal tumors
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DOI：
10.1007/s00535-007-2056-6
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发表时间：
2007-06-01
影响因子：
6.3
通讯作者：
Nakamura, Kazuhiko
中科院分区：
文献类型：
--
作者：
Ito, Tetsuhide;Tanaka, Masao;Nakamura, Kazuhiko
背景我们进行了一项全国性调查，以估计2002年至2004年日本新诊断的神经内分泌胃肠肿瘤（NETS）的发病率。方法.收集并分析了1541例患者的数据，其中514例胰腺内分泌肿瘤（PET）和1027例胃肠道类癌（GIC）。结果非功能性肿瘤（NF-PET）占PETS的47.7%。其次为胰岛素瘤（31.7%）和胃泌素瘤（8.6%）。NF-PET（46.1%）和胃泌素瘤（45.5%）中胰岛素瘤常见，但恶性胰岛素瘤仅占7.4%。与PETS相关的多发性内分泌腺瘤1型的发生率为7.4%。GIC在前肠、中肠和后肠的发生率分别为28.8%、5.2%和66.0%。类癌综合征和转移分别仅见于1.7%和5.6%的GIC。结论.这项初步研究澄清了日本NET的发病率。日本和西方国家的GIC在恶性肿瘤的位置、症状状态和患病率方面存在较大差异。
Background. We conducted a nationwide survey to estimate the incidence of neuroendocrine gastrointestinal tumors (NETS) newly diagnosed in Japan from 2002 through 2004. Methods. Data on 1541 patients, 514 pancreatic endocrine tumors (PETs) and 1027 gastrointestinal carcinoids (GICs), were collected and analyzed. Results. Nonfunctioning tumors (NF-PET) constituted 47.7% of PETS. Next in frequency were insulinoma (31.7%) and gastrinoma (8.6%). Malignancy was frequent in NF-PETs (46.1%) and gastrinomas (45.5%), but only 7.4% of insulinomas were malignant. The incidence of multiple endocrine neoplasia type-1 associated with PETS was 7.4%. The incidence of GICs was 28.8%, 5.2%, and 66.0% in foregut, midgut, and hindgut, respectively. Carcinoid syndrome and metastases were observed in only 1.7% and 5.6% of GICs, respectively. Conclusions. The incidence of NETs in Japan was clarified by this preliminary study. Comparatively large differences in GICs between Japan and Western nations were present with regard to the location, symptomatic status, and prevalence of malignancy.