Critical period of brain development in learning caused by lead exposure in rats.
Critical period of brain development in learning caused by lead exposure in rats.
复制标题
铅暴露导致大鼠大脑学习发育关键期。
DOI：
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发表时间：
1989
期刊：
影响因子：
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通讯作者：
T. Misawa
中科院分区：
文献类型：
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作者：
S. Shigeta;K. Miyake;T. Misawa
高稳定回避、低变异性的三组大鼠（a、b、c组）命名为东海高回避品系。(a)从妊娠第13天起通过胎盘，哺乳期和断奶后通过母乳喂养（pb -妊娠组），(b)哺乳期和断奶后通过母乳喂养（pb -妊娠组），(c)穿着后每10只（pb -断奶组）。产前和产后铅暴露导致学习习得速度明显延迟，并打破了男女学习习得回避率的统一性。仅在男性中，出生后接触铅会导致学习速度的轻微延迟。在佩戴后阶段，男性和女性均可观察到铅暴露导致的学习缺陷。铅暴露组和对照组幼鼠的发育无明显差异。由此可以推断，铅暴露对大鼠大脑学习发育影响最敏感的时期是出生前和出生后早期。
Three groups of rats (group a, b and c) with high and stable avoidance, and low variability, named Tokai High Avoiders (THA) strain. (a) via placenta from the 13th day of gestation, through maternal milk during lactation and per os after weaning (group Pb-gestation), (b) through maternal milk during lactation and per os after weaning (group Pb-birth), (c) per os after wearing (group Pb-weaning). The pre- and postnatal lead exposure induced apparent delays in speed of learning acquisition and broke the uniformity in avoidance rate in both males and females. Postnatal lead exposure caused slight delays in speed of learning acquisition in males alone. In the post wearing period defect in learning due to lead exposure could be observed in both males and females. No apparent difference was present in the development of pups among the lead exposed groups and control. From these results, it could be deduced that the most sensitive period of brain development in learning affected by lead exposure was the pre- and early postnatal period in the rat.