Herpes simplex virus in the respiratory tract of critical care patients: a prospective study
Herpes simplex virus in the respiratory tract of critical care patients: a prospective study
复制标题
DOI：
10.1016/s0140-6736(03)14740-x
复制
发表时间：
2003-11-08
期刊：
影响因子：
168.9
通讯作者：
Ieven, M
中科院分区：
文献类型：
--
作者：
Bruynseels, P;Jorens, PG;Ieven, M
背景单纯疱疹病毒（HSV）偶尔在重症监护患者的下呼吸道中检测到，但其在此类情况下的临床重要性尚不清楚。我们做了一项前瞻性队列研究，以确定HSV在重症监护患者呼吸道中的患病率、起源、危险因素和临床相关性。结果10例患者上呼吸道口咽拭子检出单纯疱疹病毒（HSV），764例患者中的169例（22%），其中150例（89%）在入院后10天内。在361例下呼吸道采样的患者中，有58例（16%）分离出病毒。咽喉部HSV感染是下呼吸道HSV感染的危险因素（p
Background Herpes simplex virus (HSV) is occasionally detected in the lower respiratory tract of patients in intensive care, but its clinical importance in such situations remains unclear. We did a prospective cohort study to define the prevalence, origin, risk factors, and clinical relevance of HSV in the respiratory tract of patients undergoing critical care.Methods We tested 764 patients admitted to intensive care for the presence of HSV in the respiratory tract, and assessed statistical relations between this virus and clinical variables.Findings HSV was detected by oropharyngeal swab in the upper respiratory tract of 169 (22%) of 764 patients, within 10 days of admission for 150 (89%) of these individuals. The virus was isolated in 58 (16%) of 361 patients whose lower respiratory tract was sampled. The presence of HSV in the throat was a risk factor for development of HSV infections in the lower respiratory tract (p