DROSOPHILA MUTANT WITH A TRANSDUCER DEFECT
DROSOPHILA MUTANT WITH A TRANSDUCER DEFECT
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DOI：
10.1007/bf00536455
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发表时间：
1977-01-01
期刊：
影响因子：
--
通讯作者：
MINKE, B
中科院分区：
文献类型：
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作者：
MINKE, B
这是果蝇的条件光转导突变体。直接电测量和瞬时噪声分析表明，在突变体中，长时间的强光导致量子碰撞产生的量子效率降低，而这种量子效率不是由视觉色素的漂白引起的。这种效应取决于光的持续时间，对光的强度影响很小。在正常果蝇中，强烈的蓝光将视色素从视紫红质转移到后视紫红质，诱导一个兴奋过程，表现为长时间的后电位去极化（PDA）。在突变体中，PDA具有较小的振幅，并且在响应上叠加了碰撞噪声。因此可以证明，在PDA电压响应小或不存在的突变体中，PDA的兴奋性过程也存在。这表明，突变体中PDA电压响应的缺失可能是由于连接兴奋过程和膜电导变化的中间过程的缺陷。
Thetrpis a conditional phototransduction mutant ofDrosophila. Direct electrical measurements and shot noise analysis suggest that a prolonged intense light causes in the mutant a reduction in the quantum efficiency for quantum bump production that does not arise from bleaching of the visual pigment. This effect depends on the duration of the light and only weakly on its intensity. In the normal fly, an intense blue light that shifts the visual pigment from rhodopsin to metarhodopsin, induces an excitatory process manifested by a prolonged depolarizing after potential (PDA). In the mutant, the PDA has a small amplitude and bump noise is superimposed on the response. It can thus be shown that the excitatory process underlying the PDA is also present in thosetrpmutants where the PDA voltage response is small or absent. It is suggested that the absence of the PDA voltage response in the mutant is probably due to a defect in an intermediate process, which links the excitatory process to the membrane conductance change.