Prostaglandin nomenclature.
Prostaglandin nomenclature.
复制标题
前列腺素命名法。
DOI：
10.1021/jm00255a001
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发表时间：
1974
影响因子：
7.3
通讯作者：
N. A. Nelson
中科院分区：
文献类型：
--
作者：
N. A. Nelson
这篇前列腺素命名法文章强调了半系统方法的名称派生，这种方法对书面和口头语言的快速交流特别有用。回顾了当前使用的茎名称，并特别注意描述立体化学构型、同系物、NOR化合物和某些复杂类似物的问题。在理想情况下，前列腺素命名系统应该允许名称(1)是通信的，(2)与前列腺素有关，(3)允许方便的索引和信息检索，(4)允许结构的容易可视化，以及(5)允许不同学科的科学家得出明确的结构-生物活性关系。在实际情况下，使用一个名称的化合物很难实现所有这些目标。在处理结构-生物活性研究时，对于快速交流来说，对于快速交流来说，对符合索引目的的化合物的名称可能不能令人满意，并且很可能会误导除命名学专家之外的所有专家。出于这样的原因，通常会出现替代的命名系统来满足特定群体的需求。目前《化学文摘》使用的前列腺素命名法使用前列腺素(L)1和前列腺素酸(2)2(间接)作为立体替代物或指标头亲本。这些名称意味着所示的绝对构型和数字，然后前列腺素类化合物被命名为前列腺素的衍生物，利用萜类和类固醇的命名规则3(例如，参见结构12-19中列出的姓氏)。至于是否会采用对前列腺素酸(3)1作为立体试剂，目前还不清楚。
This prostaglandin nomenclature article emphasizes name derivations by semisystematic methods which are espe-cially useful for rapid communication in the written and oral language. Currently used stem names are reviewed and special attention is given to problems of describing stereochemical configuration, homologs, nor compounds, and certain complex analogs.Under ideal circumstances, a prostaglandin nomenclature system should permit names which (1) are communi-cable,(2) relate to prostaglandins,(3) allow convenient indexing and retrieval of information,(4) allow easy visu-alization of structures, and (5) allow scientists of different disciplines to arrive at unambiguous structure-biological activity relationships. In actual circumstances, it is quite difficult to achieve all these objectivesfor a compound using a single name. Names of compounds which are sat-isfactory and proper for indexing purposes may be unsatisfactory for rapid communication and quite possibly misleading to all but nomenclature experts when dealing with structure-biological activity studies. For reasons such as these, alternative systems of nomenclature usually emerge to fill the needs of a particular group. Current prostaglandin nomenclature used by Chemical Abstracts employs prostane (l) 1 and prostanoic acid (2) 2 (indirectly) as stereoparents or index heading parents. These names imply the absolute configuration and num-bering system shown and prostaglandin-type compounds are then named as derivatives of prostane utilizing rules of terpene and steroid nomenclature3 (for examples, see the last names listed for structures 12-19). As to whether ent-prostanoic acid (3) 1 will be adopted as a stereoparent is notyet known.