Vascular Influence on Ventral Telencephalic Progenitors and Neocortical Interneuron Production.
Vascular Influence on Ventral Telencephalic Progenitors and Neocortical Interneuron Production.
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DOI：
10.1016/j.devcel.2016.02.023
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发表时间：
2016-03-21
影响因子：
11.8
通讯作者：
Shi SH
中科院分区：
文献类型：
--
作者：
Tan X;Liu WA;Zhang XJ;Shi W;Ren SQ;Li Z;Brown KN;Shi SH
新皮层包含谷氨酸能兴奋性神经元和gaba能抑制性中间神经元。广泛的研究揭示了兴奋性神经元产生的实质性见解。然而，我们对gaba能中间神经元的产生的了解仍然有限。在这里，我们显示心室周围血管选择性地影响新皮层间神经元祖细胞行为和神经发生。与背端脑不同，腹端脑负责产生新皮层中间神经元的径向胶质祖细胞（RGPs）逐渐生长出锚定在心室周围血管上的径向胶质纤维。当rgp在心室区表面进行核迁移和分裂时，这种祖血管关联是强大且积极维持的。通过选择性去除RGPs中的INTEGRIN β1破坏这种关联，导致祖细胞分裂减少，PARVALBUMIN和表达somatostatin的中间神经元丢失，以及新皮层突触抑制缺陷。这些结果突出了rgp和心室周围血管之间的显著相互作用，这对新皮层中间神经元的正常产生和功能至关重要。
The neocortex contains glutamatergic excitatory neurons and GABAergic inhibitory interneurons. Extensive studies have revealed substantial insights into excitatory neuron production. However, our knowledge of the generation of GABAergic interneurons remains limited. Here we show that periventricular blood vessels selectively influence neocortical interneuron progenitor behavior and neurogenesis. Distinct from those in the dorsal telencephalon, radial glial progenitors (RGPs) in the ventral telencephalon responsible for producing neocortical interneurons progressively grow radial glial fibers anchored to periventricular vessels. This progenitor-vessel association is robust and actively maintained as RGPs undergo interkinetic nuclear migration and divide at the ventricular zone surface. Disruption of this association by selective removal of INTEGRIN β1 in RGPs leads to a decrease in progenitor division, a loss of PARVALBUMIN and SOMATOSTATIN-expressing interneurons, and defective synaptic inhibition in the neocortex. These results highlight a prominent interaction between RGPs and periventricular vessels important for proper production and function of neocortical interneurons.