Cortical cholinergic signaling controls the detection of cues
Cortical cholinergic signaling controls the detection of cues
复制标题
DOI：
10.1073/pnas.1516134113
复制
发表时间：
2016-02-23
影响因子：
11.1
通讯作者：
Sarter, Martin
中科院分区：
文献类型：
--
作者：
Gritton, Howard J.;Howe, William M.;Sarter, Martin
皮质胆碱能输入系统被描述为影响广泛定义的行为和大脑状态的神经调质系统。发现的阶段性，试验为基础的增加细胞外胆碱（瞬态），导致新释放的乙酰胆碱（ACh）的水解，在动物的皮质报告线索的存在表明，ACh可能有一个更专门的作用，在认知过程中。在这里，我们表达了通道视紫红质或盐视紫红质在基底前脑胆碱能神经元的小鼠与光纤直接进入这一地区和前额叶皮层。胆碱能瞬变，诱发根据在体内确定的光刺激参数，在小鼠中产生的任务，需要报告的线索和noncue事件。产生胆碱能瞬变与线索增强线索检测率。此外，在非线索试验中产生的瞬变，其中胆碱能瞬变通常不会被观察到，增加了线索无效索赔的数量。增强命中和生成假警报都与刺激强度成比例。在提示试验中抑制内源性胆碱能活性降低命中率。胆碱能瞬变可能是必不可少的同步皮质神经元输出驱动的显着线索和执行线索引导的反应。
The cortical cholinergic input system has been described as a neuromodulator system that influences broadly defined behavioral and brain states. The discovery of phasic, trial-based increases in extracellular choline (transients), resulting from the hydrolysis of newly released acetylcholine (ACh), in the cortex of animals reporting the presence of cues suggests that ACh may have a more specialized role in cognitive processes. Here we expressed channel-rhodopsin or halorhodopsin in basal forebrain cholinergic neurons of mice with optic fibers directed into this region and prefrontal cortex. Cholinergic transients, evoked in accordance with photostimulation parameters determined in vivo, were generated in mice performing a task necessitating the reporting of cue and noncue events. Generating cholinergic transients in conjunction with cues enhanced cue detection rates. Moreover, generating transients in noncued trials, where cholinergic transients normally are not observed, increased the number of invalid claims for cues. Enhancing hits and generating false alarms both scaled with stimulation intensity. Suppression of endogenous cholinergic activity during cued trials reduced hit rates. Cholinergic transients may be essential for synchronizing cortical neuronal output driven by salient cues and executing cue-guided responses.