EXTENDED HLA/COMPLEMENT ALLELE HAPLOTYPES - EVIDENCE FOR T/T-LIKE COMPLEX IN MAN
EXTENDED HLA/COMPLEMENT ALLELE HAPLOTYPES - EVIDENCE FOR T/T-LIKE COMPLEX IN MAN
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DOI：
10.1073/pnas.80.1.259
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发表时间：
1983-01-01
期刊：
影响因子：
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通讯作者：
ALPER, CA
中科院分区：
文献类型：
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作者：
AWDEH, ZL;RAUM, D;ALPER, CA
本文研究了正常白种人家系中HLA-A、-B、-C和-DR等位基因以及因子B、C2和C4血清补体蛋白等位基因的染色体分布。HLA-B、DR、BF、C2、C4 A和C4 B标记的8种组合以显著高于预期的频率出现在单倍型中。在这些组合中，被定义为扩展的主要组织相容性复合体单倍型，HLA-A表现出有限的变化。一个可能的机制，为延长单倍型的维护是人类类似物的鼠t突变体，其特征在于交叉抑制和男性传播的偏见。人类6p单倍型HLA-B8、DR 3、SCO 1、GLO 2可由男性遗传给83%的后代。与GLO 1相同的单倍型无传递偏倚。这种GLO 2标记的染色体显然是一种类似于鼠t突变体的人类染色体。
The chromosomal distribution of alleles for HLA-A, -B, -C and -DR and the serum complement protein alleles of factor B and C2 and C4 was studied in normal Caucasian families. Eight combinations of HLA-B, DR, BF, C2, C4A and C4B markers occurred in haplotypes at frequencies significantly higher than expected. In these combinations, which were defined as extended major histocompatibility complex haplotypes, HLA-A showed limited variation. A possible mechanism for the maintenance of extended haplotypes are human analogs of murine t mutants which are characterized by crossover suppression and male transmission bias. One human 6p haplotype, HLA-B8, DR3, SCO1, GLO2, was transmitted from males to 83% of their offspring. The same haplotype with GLO1 had no transmission bias. This GLO2-marked chromosome apparently is a human analog of a murine t mutant.