Experimental models of hepatotoxicity related to acute liver failure.
Experimental models of hepatotoxicity related to acute liver failure.
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DOI：
10.1016/j.taap.2015.11.016
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发表时间：
2016-01-01
影响因子：
3.8
通讯作者：
Jaeschke H
中科院分区：
文献类型：
--
作者：
Maes M;Vinken M;Jaeschke H
急性肝衰竭可能是各种病因的结果，在西方国家，大多数病例是由药物诱导的肝毒性引起的。尽管在这一领域取得了进展，但急性肝功能衰竭的管理仍然是临床医学中最具挑战性的问题之一。适当的实验模型的可用性是至关重要的，以提供更好地了解这种情况，并允许识别新的药物靶点，测试新的治疗干预措施的疗效，并作为评估毒性机制的模型。与急性肝衰竭相关的肝毒性实验模型依赖于外科手术、化学暴露或病毒感染。每一种模式都有一些优点和缺点。本文特别回顾了常用的化学品在体内和体外模型的肝毒性与急性肝衰竭。
Acute liver failure can be the consequence of various etiologies, with most cases arising from drug-induced hepatotoxicity in Western countries. Despite advances in this field, the management of acute liver failure continues to be one of the most challenging problems in clinical medicine. The availability of adequate experimental models is of crucial importance to provide a better understanding of this condition and to allow identification of novel drug targets, testing the efficacy of new therapeutic interventions and acting as models for assessing mechanisms of toxicity. Experimental models of hepatotoxicity related to acute liver failure rely on surgical procedures, chemical exposure or viral infection. Each of these models has a number of strengths and weaknesses. This paper specifically reviews commonly used chemical in vivo and in vitro models of hepatotoxicity associated with acute liver failure.