β-Hexachlorocyclohexane levels in serum and risk of Parkinson's disease
β-Hexachlorocyclohexane levels in serum and risk of Parkinson's disease
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DOI：
10.1016/j.neuro.2011.04.002
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发表时间：
2011-10-01
期刊：
影响因子：
3.4
通讯作者：
German, Dwight C.
中科院分区：
文献类型：
--
作者：
Richardson, Jason R.;Roy, Ananya;German, Dwight C.
农药暴露是帕金森病（PD）发展的一个环境风险因素。然而，很少有研究确定了具体的杀虫剂。以前，我们从一个小的临床样本中发现PD患者血清中有机氯农药β-六氯环己烷（β-HCH）水平升高。在这里，我们进行了一项病例对照研究，以确认β-六氯环己烷和PD之间的关联，在一个更大的样本量（n = 283）与PD患者和控制从UT西南医学中心和埃默里大学获得的血清样本。从两个地点的两个不连续时期（2001-2003年和2006-2008年）采集了样本，并分析了乙型六氯环己烷的水平。使用logistic回归和广义估计方程估计PD的校正比值比（OR）。在这项研究中，所有队列的平均血清乙型六氯环己烷水平为22.3纳克/毫克胆固醇（范围：0-376.7），2001-2003年收集的样本的水平明显高于2006-2008年。在对年龄和性别进行控制后，血清乙型六氯环己烷每增加1纳克/毫克，患帕金森病风险增加的比值比在四个不同的队列中为1.02至1.12，在汇总分析中为1.03（95% CI：1.00-1.07，p值= 0.031）。此外，血清乙型六氯环己烷水平高于四分位数范围39.08纳克/毫克胆固醇的受试者患帕金森病风险增加的OR为2.85（95% CI：1.8，4.48; p值< 0.001）。这些数据与2001年至2008年期间环境中乙型六氯环己烷水平的下降相一致，但它们表明，血清中乙型六氯环己烷水平的升高仍然与帕金森病风险的增加有关。(C)2011 Elsevier Inc. All rights reserved.
Pesticide exposure has been implicated as an environmental risk factor for the development of Parkinson's disease (PD). However, few studies have identified specific pesticides. Previously, we identified elevated serum levels of the organochlorine pesticide beta-hexachlorocyclohexane (beta-HCH) in PD patients from a small clinical sample. Here, we conducted a case-control study to confirm the association between beta-HCH and PD in a larger sample size (n = 283) with serum samples of PD patients and controls obtained from UT Southwestern Medical Center and Emory University. Samples were obtained from two discrete periods at both sites, 2001-2003 and 2006-2008, and were analyzed for beta-HCH levels. Adjusted odds ratios (ORs) for PD were estimated using logistic regression and generalized estimating equations. The mean serum beta-HCH level across all cohorts in this study was 22.3 ng/mg cholesterol (range: 0-376.7), and the levels were significantly higher and samples collected in 2001-2003 vs. 2006-2008. After controlling for age and gender, the OR for increased risk of PD for every 1 ng/mg increase in serum beta-HCH ranged from 1.02 to 1.12 across the four different cohorts, and 1.03 (95% CI: 1.00-1.07, p value = 0.031) in the pooled analysis. Furthermore, the OR for increased risk of PD of subjects having serum beta-HCH levels above the inter-quartile range of 39.08 ng/mg cholesterol was 2.85 (95% CI: 1.8, 4.48; p value < 0.001). These data are consistent with environmental decreases in beta-HCH levels between 2001 and 2008, but they indicate that elevated levels of serum beta-HCH are still associated with heightened risk for PD. (C) 2011 Elsevier Inc. All rights reserved.