A LONGITUDINAL-STUDY OF JUNIN VIRUS ACTIVITY IN THE RODENT RESERVOIR OF ARGENTINE HEMORRHAGIC-FEVER
A LONGITUDINAL-STUDY OF JUNIN VIRUS ACTIVITY IN THE RODENT RESERVOIR OF ARGENTINE HEMORRHAGIC-FEVER
复制标题
DOI：
10.4269/ajtmh.1992.47.749
复制
发表时间：
1992-12-01
影响因子：
3.3
通讯作者：
CHILDS, JE
中科院分区：
文献类型：
--
作者：
MILLS, JN;ELLIS, BA;CHILDS, JE
我们监测朱宁病毒（JV）的活动在啮齿动物种群30个月的标记，位于农业领域和邻近的路边和围栏线在阿根廷出血热流行和非流行地区的网格。采用酶联免疫吸附试验对五周间隔捕获的啮齿动物的血液和口腔拭子进行JV抗原（Ag）分析。长颈美鼠（Calomys laucha）和长颈美鼠（C.小家鼠是最常捕获的啮齿动物，分别占捕获量的47%和22%。在41例Ag阳性捕获中，37例为C。musculinus和C. laucha; 34个来自同一地点的两个诱捕网格。抗原阳性的Calomys更常见于雄性（76%），并且在年龄最大的动物和最大的体重类别中发现的频率更高。这些模式，结合更大的流动性和更高的频率之间的伤口男性比女性，涉及水平传播的主要途径之间的合资啮齿动物传播。季节性最高水平的合资患病率（高达25%的捕获Ag阳性C musculinus）发生在Calomys的最大人口密度的时期。银阳性鼠的空间分布反映了生境偏好，大多数银阳性鼠来自边缘生境（路边和围栏线），所有银阳性鼠都来自边缘生境。劳查人是在农田里被抓的。这些不同的，但以前没有记录的，栖息地的偏好表明，在人类的疾病可能与接触的主要水库物种，C musculinus，在边境栖息地，而不是在农田。
We monitored Junin virus (JV) activity in rodent populations for 30 months at seven mark-recapture grids located in agricultural fields and adjacent roadsides and fence lines in endemic and nonendemic areas of Argentine hemorrhagic fever. Blood and oral swabs taken from rodents captured at five-week intervals were analyzed by enzyme-linked immunosorbent assay for JV antigen (Ag). Calomys laucha and C. musculinus were the most frequently captured rodents, making up 47% and 22% of captures, respectively. Of 41 Ag-positive captures, 37 were C. musculinus and four were C. laucha; 34 were from two trapping grids in the same locality. Antigen-positive Calomys were more frequently male (76%), and were found significantly more frequently among the oldest animals and the largest body mass classes. These patterns, combined with the greater mobility and higher frequencies of wounds among males than females, implicated horizontal transmission as the primary route of JV transmission between rodents. Seasonal maximum levels in JV prevalence (up to 25% of captured Ag-positive C musculinus) occurred during periods of maximal population densities of Calomys. Spatial distribution of Ag-positive rodents reflected habitat preferences; most Ag-positive C musculinus were captured from border habitats (roadsides and fence lines), and all Ag-positive C. laucha were captured in crop fields. These distinct, but previously undocumented, habitat preferences suggest that the disease in humans may be related to exposures to the primary reservoir species, C musculinus, in border habitats rather than in crop fields.