Plasma growth differentiation factors 8 and 11 levels in cats with congestive heart failure secondary to hypertrophic cardiomyopathy.
Plasma growth differentiation factors 8 and 11 levels in cats with congestive heart failure secondary to hypertrophic cardiomyopathy.
复制标题
继发于肥厚性心肌病的充血性心力衰竭猫的血浆生长分化因子 8 和 11 水平。
DOI：
10.1016/j.jvc.2019.08.002
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Lee,RT
中科院分区：
文献类型：
--
作者：
Yang,VK;Rush,JE;Bhasin,S;Wagers,AJ;Lee,RT
目的生长分化因子(GDF)11已被证明能减轻小鼠心肌肥厚。在人类中，低水平的GDF-11与心肌肥厚有关。作者假设肥厚型心肌病(HCM)猫血浆GDF-11水平降低。由于GDF-11与myostatin/GDF-8之间的同源性很高，因此GDF-8的水平也被检测了。动物37只客户所有的猫，包括心脏结构正常的猫(n=16)，肥厚性心肌病或肥厚型梗阻性心肌病(HOCM；n=14)，肥厚性心肌病并充血性心力衰竭(CHF；n=7)的猫。结果心脏结构正常的猫与有无CHF病史的HCM/HOCM猫相比，GDF-11水平无明显差异。与无心衰病史的肥厚性心肌病猫(p=0.031)和心脏结构正常的猫(p=0.027)相比，充血性心力衰竭猫的GDF8浓度降低。生长分化因子8在HOCM组比CHF组高(p=0.002)。GDF-8水平与年龄、体重或身体状况评分之间无统计学差异。结论HCM/HOCM猫与心脏结构正常的猫无论年龄大小，血浆GDF-11水平均无显著差异。CHF猫的血浆GDF-8水平低于心脏结构正常的猫和无症状的HCM/HOCM猫，提示GDF-8可能参与了CHF的发生发展。
ObjectivesGrowth differentiation factor (GDF) 11 has been shown to reduce cardiac hypertrophy in mice. Low levels of GDF-11 are associated with cardiac hypertrophy in humans. The authors hypothesized that plasma GDF-11 level is decreased in cats with hypertrophic cardiomyopathy (HCM). Given the close homology between GDF-11 and myostatin/GDF-8, GDF-8 levels were also assessed.AnimalsThirty-seven client-owned cats were enrolled, including cats with normal cardiac structure (n = 16), cats with HCM or hypertrophic obstructive cardiomyopathy (HOCM; n = 14), and cats with HCM and congestive heart failure (CHF; n = 7).MethodsPlasma samples were analyzed for GDF-8 and GDF-11 using liquid chromatography tandem-mass spectrometry. Levels of GDF-8 and GDF-11 were compared between cats with normal cardiac structure, HCM or HOCM, and CHF.ResultsNo differences in GDF-11 concentrations were found between cats with normal cardiac structure and cats with HCM/HOCM, with or without history of CHF. Decreased GDF-8 concentrations were detected in cats with CHF compared to cats with HCM/HOCM without history of CHF (p=0.031) and cats with normal cardiac structure (p=0.027). Growth differentiation factor 8 was higher in cats with HOCM compared to those with CHF (p=0.002). No statistical difference was noted in GDF-8 level as a function of age, weight, or body condition score.ConclusionsPlasma GDF-11 was not different between cats with HCM/HOCM and cats with normal cardiac structure regardless of age. Plasma GDF-8 was decreased in cats with CHF compared to cats with normal cardiac structure and cats with asymptomatic HCM/HOCM, suggesting a possible role in CHF development.