The mediation effect of posttraumatic stress disorder symptoms on the relationship of intimate partner violence and IFN-gamma levels.
The mediation effect of posttraumatic stress disorder symptoms on the relationship of intimate partner violence and IFN-gamma levels.
复制标题
创伤后应激障碍症状对亲密伴侣暴力与IFN-γ水平关系的中介作用。
DOI：
10.1007/s10464-005-6240-7
复制
发表时间：
2005
影响因子：
3.1
通讯作者：
Campbell,JacquelynC
中科院分区：
文献类型：
--
作者：
Woods,AnneB;Page,GayleG;O'Campo,Patricia;Pugh,LindaC;Ford,Daniel;Campbell,JacquelynC
背景：遭受亲密伴侣暴力 (IPV) 的女性比未受虐待的女性承受更大的压力和负面健康后果。虽然心理压力与免疫功能改变之间存在关联，但 IPV 研究尚未调查这种关系。 目的：本研究探讨了 IPV 与心理健康症状和免疫标记物的关联，以确定创伤后应激障碍 (PTSD) 症状是否介导 IPV 对促炎 (IFN-γ) 细胞因子水平的影响。方法：采用横断面比较设计来比较 62 名女性 使用 IPV 和 39 名未受虐待的女性进行研究。结果：受虐待女性和当前有 PTSD 症状的女性中 IFN-γ 平均值较高。与潜在的混杂变量没有显着关系，这些变量可以为促炎细胞因子产生的增加提供另一种解释。结论：PTSD 症状介导 IPV 和 IFN-γ 水平之间的关联，并可能部分解释 IPV 中心理健康症状与身体健康后遗症的关联。
Background: Women who experience intimate partner violence (IPV) report greater stress and negative health consequences than nonabused women. Although an association between psychological stress and altered immune function has been shown, IPV studies have not investigated this relationship.Objective: This study explored the association of IPV with mental health symptoms and an immune marker to determine if posttraumatic stress disorder (PTSD) symptoms mediate the effect of IPV on pro‐inflammatory (IFN‐γ) cytokine levels.Methods: A cross‐sectional, comparative design was used to compare 62 women with IPV and 39 nonabused women.Results: Mean IFN‐γ values were higher in abused women and in women with current PTSD symptoms. There were no significant relationships with potential confounding variables that could provide an alternative explanation for the increase in production of proinflammatory cytokines.Conclusions: PTSD symptoms mediate the association between IPV and IFN‐γ levels and may partially explain the association of mental health symptoms with physical health sequelae in IPV.