Copper deficiency alters collagen types and covalent cross-linking in swine myocardium and cardiac valves.
Copper deficiency alters collagen types and covalent cross-linking in swine myocardium and cardiac valves.
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DOI：
10.1152/ajpheart.1993.264.6.h2154
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发表时间：
1993-06
期刊：
影响因子：
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通讯作者：
R. Vadlamudi;R. McCormick;D. Medeiros;J. Vossoughi;M. Failla
中科院分区：
文献类型：
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作者：
R. Vadlamudi;R. McCormick;D. Medeiros;J. Vossoughi;M. Failla
饮食中的铜缺乏会引起结缔组织代谢的改变，这与心血管和其他器官系统的病变有关。为了确定缺铜对猪心肌和心瓣膜胶原蛋白特性的影响，给断奶猪饲喂铜含量充足或不足的日粮。尽管日粮中的铜不影响心肌或二尖瓣中的胶原蛋白浓度，但通过羟赖氨酰吡啶啉水平评估，缺铜猪的两种组织中的胶原蛋白交联程度均较低。缺铜猪的左心室和二尖瓣中 III 型胶原蛋白的比例增加。然而，铜缺乏引起心脏间质胶原部分的广泛重塑。左心室胶原交联的减少可能通过增加心室壁的顺应性来刺激心脏肥大的发展，这是严重铜缺乏的特征。与这种心脏肥大相关的胶原蛋白表型的变化表明新胶原蛋白的合成，无论铜状态如何，这都可能影响胶原蛋白交联。
Dietary copper deficiency induces alterations of connective tissue metabolism that are associated with lesions in cardiovascular and other organ systems. To determine the impact of copper deficiency on characteristics of collagen in porcine myocardium and cardiac valves, weaned pigs were fed diets with adequate or deficient levels of copper. Although dietary copper did not affect the concentration of collagen in either myocardium or bicuspid valves, the degree of collagen cross-linking, as assessed by the level of hydroxylysylpyridinoline, was lower in both tissues of copper-deficient pigs. Proportions of type III collagen were increased in the left ventricle and bicuspid valves of copper-deficient pigs. Copper deficiency induced extensive remodeling, however, of the collagen fraction of cardiac interstitium. Reduction in left ventricular collagen cross-linking may provide the stimulus for the development of cardiac hypertrophy, which characterizes severe copper deficiency, by increasing the compliance of the ventricular wall. The shift in the phenotypic profile of collagen that is associated with this cardiac hypertrophy indicates synthesis of new collagen, which could affect collagen cross-linking irrespective of copper status.