Voxel-based analysis of PET amyloid ligand [11C]PIB uptake in Alzheimer disease
Voxel-based analysis of PET amyloid ligand [11C]PIB uptake in Alzheimer disease
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DOI：
10.1212/01.wnl.0000240117.55680.0a
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发表时间：
2006-11-14
期刊：
影响因子：
9.9
通讯作者：
Rinne, J. O.
中科院分区：
文献类型：
--
作者：
Kemppainen, N. M.;Aalto, S.;Rinne, J. O.
工作背景：用N-甲基-[C-11]2-（4 '-甲基氨基苯基）-6-羟基苯并噻唑（[C-11]PIB）进行的PET研究揭示了阿尔茨海默病（AD）中几个脑区域中示踪剂摄取的增加。目的：采用基于体素的分析方法来识别AD与健康对照受试者相比[C-11]PIB摄取显著增加的脑区域，表明这些区域中淀粉样蛋白蓄积增加。方法：我们研究了17例AD患者和11例对照者的PET，使用[C-11]PIB作为示踪剂。通过计算每个体素中60至90分钟的区域与小脑的比率来计算参数图像。采用统计参数图（SPM）和自动感兴趣区（ROI）分析分析[C-11]PIB摄取的组间差异。结果如下：SPM显示额叶、顶叶和侧颞皮质以及后扣带回和纹状体的摄取增加（p < 0.001）。在初级感觉和运动皮层、初级视觉皮层、丘脑和内侧颞叶中没有发现显著的摄取差异。这些结果得到了自动ROI分析的支持，AD受试者中额叶皮层的增加最显著（[C-11]PIB摄取为对照平均值的163%）和后扣带回（146%），其次是顶叶（146%）和颞叶（145%）皮质和纹状体（133%），以及枕叶皮质（117%）和丘脑（115%）的小幅增加。结论：基于体素的分析揭示了阿尔茨海默病（AD）中[C-11]PIB摄取增加的广泛分布。这些发现与先前在尸检研究中记录的AD中淀粉样蛋白病理学的分布和阶段一致。
Background: PET studies with N-methyl-[C-11]2-(4'-methylaminophenyl)-6-hydroxybenzothiazole ([C-11]PIB) have revealed an increased tracer uptake in several brain regions in Alzheimer disease (AD). Objective: To employ voxel-based analysis method to identify brain regions with significant increases in [C-11]PIB uptake in AD vs healthy control subjects, indicative of increased amyloid accumulation in these regions. Methods: We studied 17 patients with AD and 11 control subjects with PET using [C-11]PIB as tracer. Parametric images were computed by calculating a region-to-cerebellum ratio over 60 to 90 minutes in each voxel. Group differences in [C-11]PIB uptake were analyzed with statistical parametric mapping (SPM) and automated region-of-interest (ROI) analysis. Results: SPM showed increased uptake (p < 0.001) in the frontal, parietal, and lateral temporal cortices as well as in the posterior cingulate and the striatum. No significant differences in uptake were found in the primary sensory and motor cortices, primary visual cortex, thalamus, and medial temporal lobe. These results were supported by automated ROI analysis, with most prominent increases in AD subjects in the frontal cortex ([C-11]PIB uptake 163% of the control mean) and posterior cingulate (146%) followed by the parietal (146%) and temporal (145%) cortices and striatum (133%), as well as small increases in the occipital cortex (117%) and thalamus (115%). Conclusions: Voxel-based analysis revealed widespread distribution of increased [C-11]PIB uptake in Alzheimer disease (AD). These findings are in accordance with the distribution and phases of amyloid pathology in AD, previously documented in postmortem studies.