Mechanosensitive Self-Replication Driven by Self-Organization
Mechanosensitive Self-Replication Driven by Self-Organization
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DOI：
10.1126/science.1182767
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发表时间：
2010-03-19
期刊：
影响因子：
56.9
通讯作者：
Otto, Sijbren
中科院分区：
文献类型：
--
作者：
Carnall, Jacqui M. A.;Waudby, Christopher A.;Otto, Sijbren
自我复制分子可能在生命起源中发挥了重要作用，并且已经描述了少数完全合成的自我复制因子。然而，它仍然是一个悬而未决的问题，哪些因素最有效地偏向复制远离平衡分布的特点，即使是简单的生物。我们在这里报告两个自我复制的肽衍生的大环化合物，出现从一个小的动态组合库和竞争一个共同的原料。复制是由纳米结构的形成驱动的，纳米结构的形成是由肽组装成由β片层保持在一起的纤维引起的。这两个复制因子中的哪一个成为主导因子取决于样品是摇动还是搅拌。这些结果表明，机械力可以作为一个选择压力之间的竞争复制，并可以决定共价合成的结果。
Self-replicating molecules are likely to have played an important role in the origin of life, and a small number of fully synthetic self-replicators have already been described. Yet it remains an open question which factors most effectively bias the replication toward the far-from-equilibrium distributions characterizing even simple organisms. We report here two self-replicating peptide-derived macrocycles that emerge from a small dynamic combinatorial library and compete for a common feedstock. Replication is driven by nanostructure formation, resulting from the assembly of the peptides into fibers held together by beta sheets. Which of the two replicators becomes dominant is influenced by whether the sample is shaken or stirred. These results establish that mechanical forces can act as a selection pressure in the competition between replicators and can determine the outcome of a covalent synthesis.