The role of corticothalamic coupling in human temporal lobe epilepsy
The role of corticothalamic coupling in human temporal lobe epilepsy
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DOI：
10.1093/brain/awl151
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发表时间：
2006-07-01
期刊：
影响因子：
14.5
通讯作者：
Bartolomei, Fabrice
中科院分区：
文献类型：
--
作者：
Guye, Maxime;Regis, Jean;Bartolomei, Fabrice
丘脑和颞叶结构（海马，内嗅皮层和新皮层）的EEG活动，获得脑内记录（立体脑电图，SEEG）进行TLE癫痫患者进行术前评估。使用SEEG信号相互依赖性（非线性相关性）的统计测量来研究同步性。结果表明，癫痫发作期间丘脑和颞叶结构之间的同步性总体增加。此外，尽管个体间差异很大，但我们发现癫痫发作期的值显着高于背景期的值（P = 0.001）。癫痫发作结束时的值显著高于癫痫发作时的值（P < 0.0001）。几个指数也被定义，以相关的皮质结构和丘脑之间的耦合程度的一些临床特征。在内侧TLE发作的患者中，发现丘脑皮质同步性的程度与早期意识丧失的存在之间存在相关性，但与其他临床参数无关。此外，手术预后似乎更好的患者与低值的丘脑皮质耦合在癫痫发作。这份报告表明，丘脑和远程皮质结构同步TLE癫痫发作过程中的活动，并建议癫痫网络的延伸到丘脑是一个潜在的重要因素，决定手术预后。
The EEG activity of the thalamus and temporal lobe structures (hippocampus, entorhinal cortex and neocortex) was obtained using intracerebral recordings (stereoelectroencephalography, SEEG) performed in patients with TLE seizures undergoing pre-surgical evaluation. Synchrony was studied using a statistical measure of SEEG signal interdependencies (non-linear correlation). The results demonstrated an overall increase of synchrony between the thalamus and temporal lobe structures during seizures. Moreover, although there was great inter-individual variability, we found that values from seizure onset period were significantly higher than values from the background period (P = 0.001). Values at the end of seizure were significantly higher than values from the seizure onset (P < 0.0001). Several indices were also defined in order to correlate some clinical features to the degree of coupling between cortical structures and the thalamus. In patients with mesial TLE seizures, a correlation was found between the degree of thalamocortical synchrony and the presence of an early loss of consciousness but not with other clinical parameters. In addition, surgical prognosis seemed better in patients with low values of thalamocortical couplings at the seizure onset. This report demonstrates that the thalamus and remote cortical structures synchronize their activity during TLE seizures and suggest that the extension of the epileptogenic network to the thalamus is a potential important factor determining surgical prognosis.