Molecular and clinical perspectives of polyomaviruses: emerging evidence of importance in non-kidney transplant populations.
Molecular and clinical perspectives of polyomaviruses: emerging evidence of importance in non-kidney transplant populations.
复制标题
多瘤病毒的分子和临床观点：在非肾移植人群中重要性的新证据。
DOI：
10.1002/lt.20915
复制
发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Kusne,Shimon
中科院分区：
文献类型：
--
作者：
Vilchez,RegisA;Kusne,Shimon
JC virus (JCV), BK virus (BKV) and simian virus 40 (SV40) are deoxyribonucleic acid (DNA) viruses, members of the familyPolyomaviridae. These viruses establish persistent infections, and reactivate from latency in their host under immunosuppression. During the last few years there has been recognition of the morbidity related to polyomaviruses, particularly BKV in kidney transplant recipients. More importantly, recent studies indicate the potential implication of JCV, BKV, and SV40 in renal dysfunction among nonrenal organ transplant patients. Polyomaviruses are tumor‐inducing viruses and animal models have provided evidence of the oncogenicity of these pathogens. Although data are not conclusive, molecular studies suggest an association of BKV and SV40 with malignancies among solid organ transplant patients. As new and potent immunosuppressive agents are introduced into clinical practice, it is believed that the incidence of polyomavirus‐related diseases in organ transplantation might increase. This review evaluates the biologic and epidemiologic features of these 3 viruses, the data regarding their infections in nonkidney organ transplant patients and describes future directions in the management and research of these opportunistic pathogens. Liver Transpl 12:1457–1463, 2006. © 2006 AASLD.
