Nitric oxide and salmonella pathogenesis.
Nitric oxide and salmonella pathogenesis.
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DOI：
10.3389/fmicb.2011.00084
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发表时间：
2011
影响因子：
5.2
通讯作者：
Vázquez-Torres A
中科院分区：
文献类型：
--
作者：
Henard CA;Vázquez-Torres A
一氧化氮（NO）及其同系物有助于对沙门氏菌的先天免疫反应。这种肠道病原体在脊椎动物宿主的感染周期中暴露于环境中和不同解剖位置的活性氮物质（RNS）。RNS的化学生成增强了对肠道致病菌的胃屏障，而沙门氏菌致病岛1型III分泌系统和沙门氏菌相关分子模式的产物刺激单核吞噬细胞谱系的细胞转录诱导型NO合酶（iNOS）。产生的NO，或其与氧（O2）或铁和低分子量硫醇相互作用产生的产物，优先对沙门氏菌具有抑菌作用，而NO和超氧化物（）的反应产生杀菌化合物过氧亚硝酸盐（ONOO−）。RNS的抗沙门氏菌活性源自电子传递链、中心代谢酶、转录因子以及DNA和DNA相关蛋白质的关键分子靶标的氧化还原活性硫醇和金属辅基的修饰。反过来，沙门氏菌显示出过多的防御，调节含iNOS的囊泡向吞噬体的递送，使RNS降解和解毒，并修复被这些有毒物质损坏的生物分子。传统上，RNS被认为是宿主防御沙门氏菌的重要介质。然而，令人兴奋的新发现表明，沙门氏菌可以利用感染过程中产生的RNS来培养毒力。更多的知识，主要RNS产生的沙门氏菌感染，细菌过程中受到这些有毒物种，和适应性细菌反应，保护沙门氏菌从亚硝化和氧化应激与NO将增加我们的理解沙门氏菌的发病机制。这些信息可能有助于开发针对这种常见肠道病原体的新疗法。
Nitric oxide (NO) and its congeners contribute to the innate immune response to Salmonella. This enteric pathogen is exposed to reactive nitrogen species (RNS) in the environment and at different anatomical locations during its infectious cycle in vertebrate hosts. Chemical generation of RNS enhances the gastric barrier to enteropathogenic bacteria, while products of the Salmonella pathogenicity island 1 type III secretion system and Salmonella-associated molecular patterns stimulate transcription of inducible NO synthase (iNOS) by cells of the mononuclear phagocytic cell lineage. The resulting NO, or products that arise from its interactions with oxygen (O2) or iron and low-molecular weight thiols, are preferentially bacteriostatic against Salmonella, while reaction of NO and superoxide () generates the bactericidal compound peroxynitrite (ONOO−). The anti-Salmonella activity of RNS emanates from the modification of redox active thiols and metal prosthetic groups of key molecular targets of the electron transport chain, central metabolic enzymes, transcription factors, and DNA and DNA-associated proteins. In turn, Salmonella display a plethora of defenses that modulate the delivery of iNOS-containing vesicles to phagosomes, scavenge and detoxify RNS, and repair biomolecules damaged by these toxic species. Traditionally, RNS have been recognized as important mediators of host defense against Salmonella. However, exciting new findings indicate that Salmonella can exploit the RNS produced during the infection to foster virulence. More knowledge of the primary RNS produced in response to Salmonella infection, the bacterial processes affected by these toxic species, and the adaptive bacterial responses that protect Salmonella from nitrosative and oxidative stress associated with NO will increase our understanding of Salmonella pathogenesis. This information may assist in the development of novel therapeutics against this common enteropathogen.
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DOI：
10.1073/pnas.0505401102
发表时间：
2005-11-29
影响因子：
11.1
作者：
Coombes, BK;Wickham, ME;Finlay, BB
通讯作者：
Finlay, BB
影响因子：
4.8
作者：
Bang, Iel-Soo;Liu, Limin;Fang, Ferric C.
通讯作者：
Fang, Ferric C.
影响因子：
4.8
作者：
Buzzo, Carina L.;Campopiano, Julia C.;Bortoluci, Karina R.
通讯作者：
Bortoluci, Karina R.
影响因子：
3.1
作者：
Bourret, Travis J.;Song, Miryoung;Vazquez-Torres, Andres
通讯作者：
Vazquez-Torres, Andres
DOI：
10.1073/pnas.94.25.13997
发表时间：
1997-12-09
影响因子：
11.1
作者：
DeGroote, MA;Ochsner, UA;Fang, FC
通讯作者：
Fang, FC