Choice between reinforcer delays versus choice between reinforcer magnitudes: differential Fos expression in the orbital prefrontal cortex and nucleus accumbens core.
Choice between reinforcer delays versus choice between reinforcer magnitudes: differential Fos expression in the orbital prefrontal cortex and nucleus accumbens core.
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DOI：
10.1016/j.bbr.2010.05.014
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发表时间：
2010-12-01
影响因子：
2.7
通讯作者：
Szabadi, E.
中科院分区：
文献类型：
--
作者：
Araujo, S. da Costa;Body, S.;Torres, L. Valencia;Sanchez, C. M. Olarte;Bak, V. K.;Deakin, J. F. W.;Anderson, I. M.;Bradshaw, C. M.;Szabadi, E.
关键词：
眶前额叶皮层（OPFC）和核神经元核心（AcbC）的病变可能会破坏跨时间选择任务的性能，可能是通过增加机体对延迟和/或强化幅度的敏感性。本实验研究了暴露于跨时间选择是否会诱导这些区域的神经元激活，如Fos蛋白表达增强所示。12只大鼠被训练在调节延迟时间表下按下杠杆A和B，其中A上的反应在2或18秒后递送50 μl蔗糖增溶剂，而B上的反应在根据大鼠的选择调节的延迟后递送相同的增溶剂。另外12只大鼠在类似的时间表下训练，其中A的反应提供了20或180 μl的立即释放剂，而B的反应提供了立即释放剂，其大小根据大鼠的选择进行调整。第三组接受训练的时间表，不需要变化的饼干大小或延迟，或饼干之间的选择，和对照组进行食物限制没有行为训练。与对照组相比，暴露于调节延迟时间表与OPFC和AcbC中Fos表达增强相关，而暴露于调节幅度时间表与OPFC中Fos表达增强相关，但与AcbC无关。这一结果与之前的研究结果一致，即AcbC和OPFC与延迟折扣有关，OPFC对延迟折扣的敏感性与延迟折扣的大小有关。
Lesions of the orbital prefrontal cortex (OPFC) and the nucleus accumbens core (AcbC) can disrupt performance in inter-temporal choice tasks, possibly by increasing the organism's sensitivity to delay and/or magnitude of reinforcement. This experiment examined whether exposure to an inter-temporal choice would induce neuronal activation in these areas, as indicated by enhanced expression of the Fos protein. Twelve rats were trained to press levers A and B under an adjusting-delay schedule in which a response on A delivered 50 μl of a sucrose reinforcer after 2 or 18 s, whereas a response on B delivered the same reinforcer after a delay that was adjusted in accordance with the rat's choices. Another 12 rats were trained under a similar schedule in which a response on A delivered an immediate reinforcer of size 20 or 180 μl, whereas a response on B delivered an immediate reinforcer whose size was adjusted in accordance with the rat's choices. A third group received training under a schedule that did not entail variation of reinforcer size or delay, or choice between reinforcers, and a control group underwent food restriction without behavioural training. Exposure to the adjusting-delay schedule was associated with enhanced Fos expression in both the OPFC and AcbC, whereas exposure to the adjusting-magnitude schedule was associated with enhanced Fos expression in the OPFC but not the AcbC, compared to the control group. The results are consistent with previous findings that implicated the AcbC and OPFC in delay discounting, and the OPFC in sensitivity to reinforcer size.
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