Simultaneous targeted immobilization of anti-human IgG-coated nanotubes and anti-mouse IgG-coated nanotubes on the complementary antigen-patterned surfaces via biological molecular recognition.
Simultaneous targeted immobilization of anti-human IgG-coated nanotubes and anti-mouse IgG-coated nanotubes on the complementary antigen-patterned surfaces via biological molecular recognition.
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DOI：
10.1021/ja051053p
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发表时间：
2005-06
影响因子：
15
通讯作者：
Zheyuan Zhao;I. Banerjee;H. Matsui
中科院分区：
文献类型：
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作者：
Zheyuan Zhao;I. Banerjee;H. Matsui
纳米级构建模块的自组装有望以更可复制、更高效和更经济的方式完成自下而上的制造；然而，对于更复杂的纳米级器件组件，有必要选择性地将多种类型的纳米构建块（例如金属纳米管和半导体纳米管）放置在表面的特定位置，并具有高精度和可重复性。由于自然界总是在室温下可重复地组装具有复杂功能和结构的材料，因此生物分子识别（如抗体-抗原结合）可能适合用于构建块组装。我们的方法是将抗体包被的纳米管固定在表面图案的特定互补结合位置。为了证明这一假设，通过原子力显微镜（AFM）的尖端，将两种涂有不同抗体的纳米管选择性地固定在它们互补的抗原区域上。由于这些纳米管可以被各种形态可控的金属和半导体涂覆，这一结果为完成所提出的非常规器件制造方法提供了可能性，即涂覆不同类型金属/半导体的抗体纳米管可以通过生物分子识别在抗原图案表面上自组装。
Introduction of self-assembly in nanometer-sized building blocks is expected to accomplish bottom-up fabrications in a more reproducible, efficient, and economic manner; however, it is necessary to selectively place multiple types of nano-building blocks (e.g., metal nanotubes and semiconductor nanotubes) at specific locations on surfaces with high precision and reproducibility for more complex nanometer-scale device assemblies. Biological molecular recognition such as antibody-antigen bindings may be suitable to use in the building-block assembly since nature always assembles materials with complex functions and structures at room temperature reproducibly. Our approach is to immobilize antibody-coated nanotubes at specific complementary binding positions patterned on surfaces. To demonstrate this hypothesis, two types of nanotubes coated with different antibodies were anchored selectively onto their complementary antigen areas, patterned by tips of atomic force microscope (AFM). Because those nanotubes can be coated by various metals and semiconductors with controlled morphologies, this outcome opens the possibility to accomplish the proposed unconventional device fabrication methodology that antibody nanotubes coated with different types of metals/semiconductors can be self-assembled on antigen-patterned surfaces via biological molecular recognition.