Iridium-Catalyzed Site-Selective C-H Borylation of 2-Pyridones
Iridium-Catalyzed Site-Selective C-H Borylation of 2-Pyridones
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铱催化 2-吡啶酮的位点选择性 C-H 硼化
DOI：
10.1055/s-0036-1588735
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Masahiro Miura
中科院分区：
文献类型：
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作者：
Wataru Miura;Koji Hirano;Masahiro Miura
建立了2-吡啶酮的Ir催化的C-H选择性C-H-B加成反应。中心选择性主要受空间因素控制，通过合理选择配体和溶剂，我们可以在2-吡啶酮环上获得C4、C5和C6C-H。随后，硼化产物的Suzuki-Miyaura交叉偶联也以良好的总收率生成相应的芳基化吡啶酮。
An iridium-catalyzed site-selective C–H borylation of 2-pyridones has been developed. The site selectivity is predominantly controlled by steric factors, and we can access C4, C5, and C6 C–H on the 2-pyridone ring by the judicious choice of ligand and solvent. Subsequent Suzuki–Miyaura cross-coupling of the borylated products also proceeds to form the corresponding arylated pyridones in good overall yields.