The FAB - A frontal assessment battery at bedside
The FAB - A frontal assessment battery at bedside
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DOI：
10.1212/wnl.55.11.1621
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发表时间：
2000-12-12
期刊：
影响因子：
9.9
通讯作者：
Pillon, B
中科院分区：
文献类型：
--
作者：
Dubois, B;Slachevsky, A;Pillon, B
目的：设计一种简易的床边认知行为成套测验，用于评价额叶功能。研究方法：所设计的电池包括六个子测试，探索以下内容：概念化，心理灵活性，电机编程，干扰的敏感性，抑制控制，和环境自主性。它需要大约10分钟的管理。作者研究了42名正常受试者和121名不同程度额叶功能障碍患者（PD，n = 24;多系统萎缩，n = 6;皮质基底节变性，n = 21;进行性核上性麻痹，n = 47;额颞叶痴呆，n = 25）。结果如下：额叶评估成套测验评分与Mattis痴呆评定量表评分（rho = 0.82，p < 0.01）、威斯康星州卡片分类测验的标准数（rho = 0.77，p < 0.01）和持续错误（rho = 0.68，p < 0.01）相关。这些变量在逐步多元回归中占79%的方差，而年龄或简易精神状态检查分数没有显着影响。有良好的评分者间信度（= 0.87，p < 0.001），内部一致性（Cronbach系数α 0.78）和判别效度（89.1%的病例在患者和对照组的判别分析中正确识别）。结论：额叶评定成套测验易于床边使用，对额叶功能障碍敏感。
Objective: To devise a short bedside cognitive and behavioral battery to assess frontal lobe functions. Methods: The designed battery consists of six subtests exploring the following: conceptualization, mental flexibility, motor programming, sensitivity to interference, inhibitory control, and environmental autonomy. It takes approximately 10 minutes to administer. The authors studied 42 normal subjects and 121 patients with various degrees of frontal lobe dysfunction (PD, n = 24; multiple system atrophy, n = 6; corticobasal degeneration, n = 21; progressive supranuclear palsy, n = 47; frontotemporal dementia, n = 25). Results: The Frontal Assessment Battery scores correlated with the Mattis Dementia Rating Scale scores (rho = 0.82, p < 0.01) and with the number of criteria (rho = 0.77, p < 0.01) and perseverative errors (rho = 0.68, p < 0.01) of the Wisconsin Card Sorting Test. These variables accounted for 79% of the variance in a stepwise multiple regression, whereas age or Mini-Mental State Examination scores had no significant influence. There was good interrater reliability ( = 0.87, p < 0.001), internal consistency (Cronbach's coefficient alpha 0.78), and discriminant validity (89.1% of eases correctly identified in a discriminant analysis of patients and controls). Conclusion: The Frontal Assessment Battery is easy to administer at bedside and is sensitive to frontal lobe dysfunction.