The cancer stem cell concept in progression of head and neck cancer.
The cancer stem cell concept in progression of head and neck cancer.
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DOI：
10.1155/2009/894064
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发表时间：
2009
影响因子：
--
通讯作者：
Chen ZG
中科院分区：
文献类型：
--
作者：
Chen ZG
人头颈部癌（HNC）是一种高度异质性的疾病。了解HNC进展的生物学对于开发新的预防，早期检测和治疗方法是必要的。目前的进化进展模型在解释单个肿瘤巢中观察到的异质性方面存在局限性。越来越多的证据支持癌症干细胞（CSC）作为实体瘤（包括HNC）中的小亚群存在。这些CSC可以通过适当的细胞表面标志物来选择，这些细胞表面标志物是癌症类型特异性的，并且已经通过独特的体外和体内测定来证实。选定的CSC群体保持自我更新能力，并显示出攻击性行为，如化学抗性和转移。除了介绍实体瘤中的CSC概念外，本文还总结了目前HNC CSC的出版物以及CSC概念在临床上对HNC的前瞻性发展和应用。
Human head and neck cancer (HNC) is a highly heterogeneous disease. Understanding the biology of HNC progression is necessary for the development of novel approaches to its prevention, early detection, and treatment. A current evolutional progression model has limitations in explaining the heterogeneity observed in a single tumor nest. Accumulating evidence supports the existence of cancer stem cells (CSCs) as small subpopulations in solid tumors, including HNC. These CSCs can be selected by appropriate cell surface markers, which are cancer type specific and have been confirmed by unique in vitro and in vivo assays. Selected CSC populations maintain a self-renewal capability and show aggressive behaviors, such as chemoresistance and metastasis. In addition to introducing the CSC concept in solid tumors, this short review summarizes current publications in HNC CSC and the prospective development and application of the CSC concept to HNC in the clinic.