Adaptive survival trials.
Adaptive survival trials.
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DOI：
10.1080/10543409708835211
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发表时间：
1997-11-01
影响因子：
1.1
通讯作者：
Seshaiyer, P
中科院分区：
文献类型：
--
作者：
Rosenberger, W F;Seshaiyer, P
我们提出了一个自适应生存试验的设计，其中随机化到两个治疗之一的概率偏离0.5，根据当前值的对数秩统计。给出了将对数秩统计量映射到[0，1]的公式，然后使用该公式来偏置用于随机化的硬币。模拟证据表明，分配方案工作良好，并提供了一个更道德的替代终身数据时，从其他患者在招募期间。权力不会受到由此产生的不平等分配的不利影响。在建议的分配方案下，通常的检验统计量似乎是标准正态的。
We present a design for adaptive survival trials, where the probability of randomization to one of two treatments is skewed away from 0.5 according to the current value of the logrank statistic. A formula mapping the logrank statistic onto [0,1] is given, which is then used to bias a coin used for randomization. Simulation evidence shows that the allocation scheme works well and offers a more ethical alternative when lifetime data are available from other patients during the recruitment period. Power is not adversely affected by the resulting unequal allocation. The usual test statistic appears to be standard normal under the proposed allocation scheme.