Alterations of "sleeping time" in the rat induced by drugs which modulate central monoaminergic systems.
Alterations of "sleeping time" in the rat induced by drugs which modulate central monoaminergic systems.
复制标题
调节中枢单胺能系统的药物引起大鼠“睡眠时间”的改变。
DOI：
10.1093/bja/64.5.594
复制
发表时间：
1990
影响因子：
9.8
通讯作者：
A. Majeed
中科院分区：
文献类型：
--
作者：
A. Angel;A. Majeed
已经确定了肾上腺素能受体激动剂和拮抗剂对大鼠“睡眠时间”的影响，即在动物一动不动并采取睡眠姿势的情况下。他们的总体行为模式的改变也被评估。特异性α - 2-肾上腺素受体激动剂（育亨宾，WY 26393， RX 781094和RS 21361）减少睡眠时间，β -肾上腺素受体激动剂克伦特罗也如此。特定的- 2肾上腺素能受体激动剂可乐定在剂量超过25微克公斤-1时，会大大增加睡眠时间。β -拮抗剂心得安和特异性β - 2拮抗剂ICI 118551也有同样的效果。
The effects of adrenoceptor agonists and antagonists have been determined on "sleeping time" in the rat--that is, with the animal immobile and adopting a sleeping posture. Alterations in their gross behaviour patterns were assessed also. The specific alpha 2-adrenoceptor agonists (yohimbine, WY 26393, RX 781094 and RS 21361) decreased sleeping time, as did the beta-adrenoceptor agonist clenbuterol. The specific alpha 2-adrenoceptor agonist clonidine gave a large increase in sleeping time at doses in excess of 25 micrograms kg-1. The same effect was seen with the beta-antagonist propranolol and the specific beta 2-antagonist ICI 118551.