Brain regions expressing Fos during thermoregulatory behavior in rats
Brain regions expressing Fos during thermoregulatory behavior in rats
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DOI：
10.1152/ajpregu.00166.2002
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发表时间：
2003-11-01
影响因子：
2.8
通讯作者：
Kanosue, K
中科院分区：
文献类型：
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作者：
Maruyama, M;Nishi, M;Kanosue, K
我们通过对大鼠大脑中 Fos 蛋白表达的免疫组织化学分析来调查神经基质的行为温度调节。我们使用了一个操作系统，其中暴露在高温（40 摄氏度）下的老鼠在进入奖励区域时可以得到冷空气（0 摄氏度）30 秒。老鼠定期进出系统的奖励区域，从而将体温保持在正常水平。在进行热逃逸行为的大鼠（活跃组）中，与对照组相比，在正中视前核（MnPO）、旁房核（PS）和下丘脑背内侧核（DMH）中发现了较强的Fos免疫反应性（Fos-IR）。另一组大鼠（被动组）受到与主动组大鼠相同的温度变化，无论大鼠如何运动。 MnPO 中的 Fos-IR 也出现在该组中。目前的结果表明，PS 和 DMH 在体温调节行为的发生中发挥着重要作用，而 MnPO 对于检测环境温度和/或体温的变化可能很重要。
We surveyed the neural substrata for behavioral thermoregulation with immunohistochemical analysis of the expression of Fos protein in the rat brain. We used an operant system in which a rat exposed to heat ( 40 degreesC) could get cold air ( 0 degreesC) for 30 s when it moved into the reward area. Rats moved in and out of the reward area of the system periodically and thus maintained their body temperature at a normal level. In the rats performing heat escape behavior ( active group), strong Fos immunoreactivity (Fos-IR) was found in the median preoptic nucleus (MnPO), parastrial nucleus ( PS), and dorsomedial hypothalamus (DMH) compared with the controls. Another group of rats ( passive group) were given the same temperature changes, regardless of the rat's movement, as those obtained by rats of the active group. Fos-IR in the MnPO was also seen in this group. The present results suggest that the PS and DMH play an important role in the genesis of thermoregulatory behavior, whereas the MnPO may be important for detecting changes in ambient and/or body temperatures.