Evidence for brain morphometric changes during the migraine cycle: A magnetic resonance-based morphometry study
Evidence for brain morphometric changes during the migraine cycle: A magnetic resonance-based morphometry study
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DOI：
10.1177/0333102414559732
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发表时间：
2015-08-01
期刊：
影响因子：
4.9
通讯作者：
Pierelli, Francesco
中科院分区：
文献类型：
--
作者：
Coppola, Gianluca;Di Renzo, Antonio;Pierelli, Francesco
神经生理学研究表明，偏头痛发作期和发作间期之间的大脑功能活动存在独特的波动。在这里，我们研究了无先兆发作性偏头痛 (MO) 患者的全脑形态测量随时间变化的可能性。 24 名未经治疗的 MO 患者在发作期间（n = 10）或发作之间（n = 14）接受了 3T MRI 扫描，并与一组 15 名健康志愿者 (HV) 进行比较。然后，我们对结构 T1 加权 MRI 扫描进行基于体素的形态测量 (VBM) 分析，以确定在偏头痛周期过程中是否观察到大脑结构的变化。发作间期，MO 患者的右顶下小叶、右颞下回、右颞上回和左颞极内的灰质 (GM) 密度显着低于 HV 患者。发病期间，左侧颞极、双侧岛叶和右侧豆状核内的 GM 密度增加，但没有区域表现出 GM 密度降低。发作期和发作间期之间的这些形态测量 GM 变化表明异常的结构可塑性可能是偏头痛病理学的重要机制。鉴于这些区域的功能神经解剖学，我们的研究结果表明偏头痛是一种与多感觉整合和记忆处理的整体功能障碍相关的疾病。
Neurophysiological investigations have demonstrated that there are unique fluctuations in the migraine brain functional activity between the ictal and interictal periods. Here we investigated the possibility that there are fluctuations over time also in whole brain morphometry of patients affected by episodic migraine without aura (MO). Twenty-four patients with untreated MO underwent 3T MRI scans during (n=10) or between attacks (n=14) and were compared to a group of 15 healthy volunteers (HVs). We then performed voxel-based-morphometry (VBM) analysis of structural T1-weighted MRI scans to determine if changes in brain structure were observed over the course of the migraine cycle. Interictally, MO patients had a significantly lower gray matter (GM) density within the right inferior parietal lobule, right temporal inferior gyrus, right superior temporal gyrus, and left temporal pole than did HVs. Ictally, GM density increased within the left temporal pole, bilateral insula, and right lenticular nuclei, but no areas exhibited decreased GM density. These morphometric GM changes between ictal and interictal phases suggest that abnormal structural plasticity may be an important mechanism of migraine pathology. Given the functional neuroanatomy of these areas, our findings suggest that migraine is a condition associated with global dysfunction of multisensory integration and memory processing.