Apolipoprotein E genotype is associated with serum C-reactive protein but not abdominal aortic aneurysm
Apolipoprotein E genotype is associated with serum C-reactive protein but not abdominal aortic aneurysm
复制标题
DOI：
10.1016/j.atherosclerosis.2009.09.027
复制
发表时间：
2010-04-01
期刊：
影响因子：
5.3
通讯作者：
Norman, Paul E.
中科院分区：
文献类型：
--
作者：
Golledge, Jonathan;Biros, Erik;Norman, Paul E.
目的：载脂蛋白E（ApoE）基因型与系统性贫血有关。然而，与腹主动脉瘤（AAA）的相关性先前尚未研究。我们评估了载脂蛋白E基因型与AAA的存在和增长，血清C反应蛋白（CRP）之间的关联。方法：CRP（在1358名男子）和6个单核苷酸多态性（SNP）的载脂蛋白E（在1711名男子）的血清浓度进行了检查，在男性健康研究的主题。对640例小AAA患者进行了平均4.1年的超声监测，结果：ApoE基因型与AAA的存在无相关性。ApoE p.Arg176Cys多态性杂合子男性AAA生长较慢，AAA进展的比值比>=中位数0.41，95%置信区间0.21-0.80，p=0.01。男性ApoE基因杂合子g. 50093756 A>G多态性的AAA生长略快，AAA进展的比值比>=中位数1.48，95%置信区间1.02-2.14，p=0.04。然而，考虑到多次测试，ApoE SNP均与AAA生长无关。在共显性模型下，ApoE中的两个SNP与血清CRP相关，ApoE p.Cys130Arg（SNP ID rs 429358），p=0.00003和ApoE g.50114786A> G（SNP ID rs 4420638），p=0.00013。在显性模型下，校正其他危险因素和血清肌酐后，ApoE基因型与低血清CRP相关，相关系数为0.089，p= 0.002。结论：ApoE基因型与AAA无一致性关联。我们证实了ApoE基因型和血清CRP之间的关联。(C)2009爱思唯尔爱尔兰有限公司保留所有权利。
Objective: Apolipoprotein E (ApoE) genotype has been associated with systemic in. ammation and atherothrombosis however the association with abdominal aortic aneurysm (AAA) has not been previously examined. We assessed the association between ApoE genotype with AAA presence and growth, and serum C-reactive protein (CRP).Methods: Serum concentrations of CRP (in 1358 men) and 6 single nucleotide polymorphisms (SNPs) for ApoE (in 1711 men) were examined in subjects from the Health In Men Study. 640 men with small AAAs were followed by ultrasound surveillance for a mean of 4.1 years.Results: There was no association between ApoE genotype and AAA presence. Men heterozygote for the ApoE p.Arg176Cys polymorphism had slower AAA growth, odds ratio for AAA progression >= median 0.41, 95% confidence intervals 0.21-0.80, p=0.01. Men heterozygote for the ApoE g. 50093756A>G polymorphism had slightly more rapid AAA growth, odds ratio for AAA progression >= median 1.48, 95% confidence intervals 1.02-2.14, p=0.04. None of the ApoE SNPs were associated with AAA growth however taking into account multiple testing. Two SNPs in ApoE were associated with serum CRP under a co-dominant model, ApoE p. Cys130Arg (SNP ID rs429358), p=0.00003 and ApoE g.50114786A> G (SNP ID rs4420638), p=0.00013. Adjusting for other risk factors plus serum creatinine the epsilon 4 allele was associated with lower serum CRP under a dominant model, coefficient 0.089, p=0.002.Conclusion: We found no consistent association between ApoE genotype and AAA. We confirmed an association between ApoE genotype and serum CRP. (C) 2009 Elsevier Ireland Ltd. All rights reserved.