Heritable Epigenetic Changes Alter Transgenerational Waveforms Maintained by Cycling Stores of Information.
Heritable Epigenetic Changes Alter Transgenerational Waveforms Maintained by Cycling Stores of Information.
复制标题
可遗传的表观遗传变化改变了由循环信息存储维持的跨代波形。
DOI：
10.1002/bies.201900254
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Jose,AntonyM
中科院分区：
文献类型：
--
作者：
Jose,AntonyM
我们对遗传的看法可能会被轻易地在复制的基因序列中引入可遗传的变化，而不是在基因序列周围调节因子的循环组装中引入可遗传的变化而扭曲。在这里，已经告知遗传的理解的关键实验被重新解释，以突出这种扭曲和可能的各种可遗传的变化被考虑。可遗传的遗传变化总是与基因序列的突变有关，而可遗传的表观遗传变化可以与分子的物理或化学变化有关，也可以只与系统的变化有关。循环储存的传递沿着连接连续几代的连续细胞谱系产生活动波和分子定位，这些分子共同形成每一代细胞发育的密码。因此，可遗传的表观遗传变化可以包括任何可以改变波的变化，如形式、中线、频率、振幅或相位的变化。测试这种对所有遗传信息的综合观点，将需要跨代协调地应用多种实验方法。
Our view of heredity can potentially be distorted by the ease of introducing heritable changes in the replicating gene sequences but not in the cycling assembly of regulators around gene sequences. Here, key experiments that have informed the understanding of heredity are reinterpreted to highlight this distortion and the possible variety of heritable changes are considered. Unlike heritable genetic changes, which are always associated with mutations in gene sequence, heritable epigenetic changes can be associated with physical or chemical changes in molecules or only changes in the system. The transmission of cycling stores along the continuous lineage of cells that connects successive generations creates waves of activity and localization of the molecules that together form the cell code for development in each generation. As a result, heritable epigenetic changes can include any that can alter a wave such as changes in form, midline, frequency, amplitude, or phase. Testing this integrated view of all heritable information will require the concerted application of multiple experimental approaches across generations.