A soft, wearable microfluidic device for the capture, storage, and colorimetric sensing of sweat.
A soft, wearable microfluidic device for the capture, storage, and colorimetric sensing of sweat.
复制标题
DOI：
10.1126/scitranslmed.aaf2593
复制
发表时间：
2016-11-23
影响因子：
17.1
通讯作者：
Rogers JA
中科院分区：
文献类型：
--
作者：
Koh A;Kang D;Xue Y;Lee S;Pielak RM;Kim J;Hwang T;Min S;Banks A;Bastien P;Manco MC;Wang L;Ammann KR;Jang KI;Won P;Han S;Ghaffari R;Paik U;Slepian MJ;Balooch G;Huang Y;Rogers JA
通过汗液的捕获和定量化学分析进行健康监测的能力可以补充或潜在地减少对基于血液样本的零星评估的方法的需求。已建立的汗液监测技术使用简单的织物样本，并仅限于在受控实验室或医院环境中进行基本分析。我们提出了用于柔软、柔性和可拉伸微流体系统的材料和装置设计的集合，包括集成无线通信电子器件的实施例，其可以紧密且稳健地结合到皮肤表面而没有化学和机械刺激。这种整合为一小组汗腺定义了接入点，使得汗液自发地启动汗液通过微流体网络和一组储液器的路由。嵌入式化学分析以比色方式响应标记物，如氯离子和水合氢离子，葡萄糖和乳酸盐。数字图像采集硬件的无线接口可用作定量手段。人体研究证明了这种微流体装置在受控环境中的健身自行车运动和在干旱户外条件下的长距离自行车比赛中的功能。结果包括出汗率、总出汗量、pH值以及氯化物和乳酸盐的浓度的定量值。
Capabilities in health monitoring via capture and quantitative chemical analysis of sweat could complement, or potentially obviate the need for, approaches based on sporadic assessment of blood samples. Established sweat monitoring technologies use simple fabric swatches and are limited to basic analysis in controlled laboratory or hospital settings. We present a collection of materials and device designs for soft, flexible and stretchable microfluidic systems, including embodiments that integrate wireless communication electronics, which can intimately and robustly bond to the surface of skin without chemical and mechanical irritation. This integration defines access points for a small set of sweat glands such that perspiration spontaneously initiates routing of sweat through a microfluidic network and set of reservoirs. Embedded chemical analyses respond in colorimetric fashion to markers such as chloride and hydronium ions, glucose and lactate. Wireless interfaces to digital image capture hardware serve as a means for quantitation. Human studies demonstrated the functionality of this microfluidic device during fitness cycling in a controlled environment and during long-distance bicycle racing in arid, outdoor conditions. The results include quantitative values for sweat rate, total sweat loss, pH and concentration of both chloride and lactate.