Korean red ginseng powder in the treatment of melasma: an uncontrolled observational study.
Korean red ginseng powder in the treatment of melasma: an uncontrolled observational study.
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DOI：
10.5142/jgr.2011.35.2.170
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发表时间：
2011-06
影响因子：
6.3
通讯作者：
Kim MB
中科院分区：
文献类型：
--
作者：
Song M;Mun JH;Ko HC;Kim BS;Kim MB
日晒、紫外线照射和氧化应激是造成黄褐斑的主要病因。高丽红参粉的成分，包括人参皂苷和酚类化合物，具有抗氧化作用，减少紫外线b诱导的色素沉着。本研究旨在评价红参粉治疗黄褐斑的有效性和安全性。25例女性患者口服高丽红参粉3 g，持续24周。通过黄褐斑面积和严重程度指数（MASI）、黄褐斑生活质量量表（MELASQoL）以及患者和研究者评定的总体改善量表来确定色素沉着和红斑的水平，并评估临床改善情况。24周后，MASI评分由8.8降至5.6,91%的患者MELASQoL改善（p<0.05）。平均色素沉着水平由184.3降至159.7，红斑水平由253.6降至216.4 （p<0.05）。此外，在第24周，74%的患者在患者和研究者评定的总体改善量表上都有一定的改善。红参粉对大多数患者的耐受性良好。结论：红参粉对黄褐斑患者具有良好的耐受性和有益作用。红参是治疗黄褐斑的一种有效的辅助疗法。
Exposure to the sun, ultraviolet radiation, and oxidative stress are the chief etiologic factors responsible for melasma. The ingredients of Korean red ginseng powder, which include ginsenoside and phenolic compounds, have antioxidative effects and reduce ultraviolet B-induced pigmentation. This study was designed to evaluate the effectiveness and safety of Korean red ginseng powder in patients with melasma. In 25 female patients, 3 g of Korean red ginseng powder was orally administered for a 24 week period. The level of pigmentation and erythema were determined and clinical improvement was evaluated by the melasma area and severity index (MASI), melasma quality of life scale (MELASQoL), and patient- and investigator-rated global improvement scale. After 24 weeks, the MASI score decreased from 8.8 to 5.6, and MELASQoL showed improvement in 91% of patients (p<0.05). The mean level of pigmentation decreased from 184.3 to 159.7 and erythema levels decreased from 253.6 to 216.4 (p<0.05). Additionally, 74% of the patients showed some improvement in both patient- and investigator-rated global improvement scales at week 24. Korean red ginseng powder was well tolerated by most of the patients. In conclusion, Korean red ginseng powder showed good tolerability and beneficial effects in patients with melasma. The use of Korean red ginseng would be counted as a useful adjunctive therapy for patients with melasma.
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DOI：
10.1111/j.1600-0749.1997.tb00475.x
发表时间：
1997-06-01
期刊：
PIGMENT CELL RESEARCH
影响因子：
--
作者：
Kahn, V;BenShalom, N
通讯作者：
BenShalom, N
影响因子：
3.6
作者：
Kim, EJ;Park, HY;Gilchrest, BA
通讯作者：
Gilchrest, BA
DOI：
10.1073/pnas.93.3.1087
发表时间：
1996-02-06
影响因子：
11.1
作者：
Eller, MS;Ostrom, K;Gilchrest, BA
通讯作者：
Gilchrest, BA
DOI：
10.1034/j.1600-0749.2000.130509.x
发表时间：
2000-10-01
期刊：
PIGMENT CELL RESEARCH
影响因子：
--
作者：
Horikoshi, T;Nakahara, M;Miyachi, Y
通讯作者：
Miyachi, Y
影响因子：
10.3
作者：
Kang, WH;Yoon, KH;Im, S
通讯作者：
Im, S