CTCF: insights into insulator function during development
CTCF: insights into insulator function during development
复制标题
DOI：
10.1242/dev.065268
复制
发表时间：
2012-03-15
期刊：
影响因子：
4.6
通讯作者：
Renkawitz, Rainer
中科院分区：
文献类型：
--
作者：
Herold, Martin;Bartkuhn, Marek;Renkawitz, Rainer
高等真核生物的基因组显示出非活性基因和活性基因的拼凑。核蛋白ccctc结合因子（CTCF）与绝缘子序列结合时，可以防止活性和非活性基因组区域之间的不良串扰，还可以保护特定基因不受增强子功能的影响，这一作用在开发中有许多应用。最近令人兴奋的工作已经证明了CTCF在胚胎、神经元和造血发育中的作用。在这里，我们讨论了与模式基因相关的CTCF依赖性转录发育调节的潜在机制，并强调了全基因组的结果，表明CTCF可能在整个基因组的激活和抑制转录事件中发挥主要作用。
The genome of higher eukaryotes exhibits a patchwork of inactive and active genes. The nuclear protein CCCTC-binding factor (CTCF) when bound to insulator sequences can prevent undesirable crosstalk between active and inactive genomic regions, and it can also shield particular genes from enhancer function, a role that has many applications in development. Exciting recent work has demonstrated roles for CTCF in, for example, embryonic, neuronal and haematopoietic development. Here, we discuss the underlying mechanisms of developmentally regulated CTCF-dependent transcription in relation to model genes, and highlight genome-wide results indicating that CTCF might play a master role in regulating both activating and repressive transcription events at sites throughout the genome.