Longitudinal study of dental caries incidence associated with Streptococcus mutans and Streptococcus sobrinus in pre-school children
Longitudinal study of dental caries incidence associated with Streptococcus mutans and Streptococcus sobrinus in pre-school children
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DOI：
10.1099/jmm.0.46069-0
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发表时间：
2005-07-01
影响因子：
3
通讯作者：
Kozai, K
中科院分区：
文献类型：
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作者：
Okada, M;Soda, Y;Kozai, K
已知变形链球菌和远缘链球菌与龋齿的发展有关。在这项研究中，这些细菌检测学龄前儿童（每个乳牙，年龄范围3-5岁，n = 60）使用PCR方法，然后他们的存在与龋齿的发病率超过1年的时间进行了比较。使用无菌牙刷从所有萌出的牙齿部位收集菌斑样本。在研究开始时（基线）和1年后进行牙科检查，以确定龋坏，缺失，填补牙齿（dmft）评分使用世界卫生组织龋齿诊断标准。S. mutans和S.在所有受试者中，sobrinus分别为61.7%和56.6%，13例受试者（21.7%）为S阳性。变形链球菌阳性10例（116.6%）。24例（40.0%）为两种S. mutans和S. sobrinus阴性13例（21.7%）。mutans和S. sobrinus。两种S. mutans和S.在基线和1年后，sobrinus显著高于S.在同一时期，单独的变形链球菌（P < 0.01和P < 0.001）。两种细菌同时检出者的龋增量也显著高于对照组（P < 0.05）。我们的研究结果表明，学龄前儿童同时携带S。mutans和S. sobrinus的龋齿发病率显著高于S.变种人单独
Streptococcus mutans and Streptococcus sobrinus are known to be associated with the development of dental caries. In this study these bacteria were detected in pre-school children (each with primary dentition, age range 3-5 years, n = 60) using a PCR method, and then their presence was compared with the incidence of dental caries over a 1-year period. Plaque samples were collected from all erupted tooth sites using a sterile toothbrush. Dental examinations atthe beginning of the study (baseline) and after 1 year were also performed to determine decayed, missing, filled teeth (dmft) scores using WHO caries diagnostic criteria. The prevalences of S. mutans and S. sobrinus across all the subjects were 61.7% and 56.6%, respectively; 13 subjects (21.7%) were positive for S. mutans alone, 10 (116.6%) were positive for S. sobrinus alone and 24 (40.0%) were positive for both S. mutans and S. sobrinus, whereas 13 (21.7%) were negative for both S. mutans and S. sobrinus. dmft scores of subjects positive for both S. mutans and S. sobrinus at baseline and after 1 year were significantly higher than of those positive for S. mutans alone at the same stages (P < 0.01 and P < 0.001, respectively). The caries incremental increase was also significantly greater in those with both bacteria detected (P < 0.05). Our results indicate that pre-school children harbouring both S. mutans and S. sobrinus have a significantly higher incidence of dental caries than those with S. mutans alone.