Prefrontal cortex function in the representation of temporally complex events
Prefrontal cortex function in the representation of temporally complex events
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DOI：
10.1523/jneurosci.0633-08.2008
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发表时间：
2008-04-09
影响因子：
5.3
通讯作者：
Gaffan, David
中科院分区：
文献类型：
--
作者：
Browning, Philip G. F.;Gaffan, David
额叶皮层和下颞叶皮层在功能上紧密相连。先前对猴子前额叶功能的实验表明，前额叶皮层与下颞叶皮层的断开会损害各种复杂的视觉学习任务，但会完好无损地保留简单的并发对象奖励关联学习。我们通过向并发对象奖励关联学习任务添加特定的时间成分，研究了视觉学习任务的时间成分决定这些任务对前额叶颞叶断开的敏感性的可能性。与未手术的对照组相比，前额叶皮层和颞下皮层单侧交叉损伤的猴子在将视觉对象的两项序列与奖励相关联方面受到损害。这种损害是视觉序列学习所特有的，因为断开连接对同等延迟奖励的对象奖励关联学习没有影响。这一结果在猴子钩突束横断中得到复制，从而确定了解离的解剖学特异性。先前的行为结果表明，猴子以配置方式表示两项连续复合刺激，类似于猴子表示同时呈现的复合刺激的方式。同时呈现的配置刺激的表示取决于鼻周皮层。目前的实验表明，连续呈现的复合刺激的表征取决于前额叶皮层和下颞叶皮层的相互作用。我们认为，前额叶-颞叶脱节会损害多种学习任务，因为在这些任务中，猴子会做出类似的时间复杂表征。
The frontal cortex and inferior temporal cortex are strongly functionally interconnected. Previous experiments on prefrontal function in monkeys have shown that a disconnection of prefrontal cortex from inferior temporal cortex impairs a variety of complex visual learning tasks but leaves simple concurrent object-reward association learning intact. We investigated the possibility that temporal components of visual learning tasks determine the sensitivity of those tasks to prefrontal-temporal disconnection by adding specific temporal components to the concurrent object-reward association learning task. Monkeys with crossed unilateral lesions of prefrontal cortex and inferior temporal cortex were impaired compared with unoperated controls at associating two-item sequences of visual objects with reward. The impairment was specific to the learning of visual sequences, because disconnection was without effect on object-reward association learning for an equivalent delayed reward. This result was replicated in monkeys with transection of the uncinate fascicle, thus determining the anatomical specificity of the dissociation. Previous behavioral results suggest that monkeys represent the two-item serial compound stimuli in a configural manner, similar to the way monkeys represent simultaneously presented compound stimuli. The representation of simultaneously presented configural stimuli depends on the perirhinal cortex. The present experiments show that the representation of serially presented compound stimuli depends on the interaction of prefrontal cortex and inferior temporal cortex. We suggest that prefrontal-temporal disconnection impairs a wide variety of learning tasks because in those tasks monkeys lay down similar temporally complex representations.