The Extrapyramidal Symptom Rating Scale and Its Abbreviated Version: A Critical Review of Clinimetric Properties.
The Extrapyramidal Symptom Rating Scale and Its Abbreviated Version: A Critical Review of Clinimetric Properties.
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锥体外系症状评定量表及其缩写版本：临床测量特性的批判性回顾。
DOI：
10.1159/000535113
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发表时间：
2023
影响因子：
22.8
通讯作者：
Alphs,Larry
中科院分区：
文献类型：
--
作者：
Chouinard,Guy;Cosci,Fiammetta;Chouinard,Virginie-Anne;Alphs,Larry
锥体外系症状评定量表（ESRS-A）是锥体外系症状评定量表（ESRS）的简化版本，包括说明、定义和遵循临床测量概念测量临床症状的半结构化访谈。与ESRS相似，ESRS-A被开发用于评估四种类型的药物诱导的运动障碍（DIMD）：帕金森综合征、静坐不能、肌张力障碍和迟发性运动障碍（TD）。提供了全面的ESRS-A定义、官方量表和基本说明。在两项关键性研究和多中心国际研究中评价了ESRS评定者间可靠性。评估者间的可靠性很高，用于评估抗精神病药引起的运动障碍和特发性帕金森病。还制定了关于评级人之间可靠性和评级人认证程序的准则。ESRS具有良好的同时效度，TD定义病例的异常不自主运动量表（AIMS）与ESRS定义病例的一致率为96%。同样，ESRS-A总分和帕金森综合征、静坐不能、肌张力障碍和运动障碍分项评分的并行有效性范围为良好至非常好。ESRS对检测安慰剂、抗精神病药、抗帕金森病药和抗运动障碍药物治疗后的DIMM相关运动差异特别敏感。ESRS测量药物引起的锥体外系症状被证明是区分锥体外系症状和精神症状。它们可以在临床研究中有价值地实施，特别是在测试抗精神病药物的试验中，以及在诊所中检测运动障碍的存在、严重程度和对治疗的反应。
BackgroundThe Extrapyramidal Symptom Rating Scale–Abbreviated (ESRS-A) is an abbreviated version of the Extrapyramidal Symptom Rating Scale (ESRS) with instructions, definitions, and a semi-structured interview that follows clinimetric concepts of measuring clinical symptoms. Similar to the ESRS, the ESRS-A was developed to assess four types of drug-induced movement disorders (DIMD): parkinsonism, akathisia, dystonia, and tardive dyskinesia (TD).SummaryThe present review of the literature provides the most relevant clinimetric properties displayed by the ESRS and ESRS-A in clinical studies. Comprehensive ESRS-A definitions, official scale, and basic instructions are provided. ESRS inter-rater reliability was evaluated in two pivotal studies and in multicenter international studies. Inter-rater reliability was high for assessing both antipsychotic-induced movement disorders and idiopathic Parkinson’s disease. Guidelines were also established for inter-rater reliability and the rater certification processes. The ESRS showed good concurrent validity with 96% agreement between Abnormal Involuntary Movement Scale (AIMS) for TD-defined cases and ESRS-defined cases. Similarly, concurrent validity for ESRS-A total and subscores for parkinsonism, akathisia, dystonia, and dyskinesia ranged from good to very good. The ESRS was particularly sensitive for detecting DIMD-related movement differences following treatment with placebo, antipsychotics, and antiparkinsonian and antidyskinetic medications. ESRS measurement of drug-induced extrapyramidal symptoms was shown to discriminate extrapyramidal symptoms from psychiatric symptoms.Key MessagesThe ESRS and ESRS-A are valid clinimetric indices for measuring DIMD. They can be valuably implemented in clinical research, particularly in trials testing antipsychotic medications, and in clinics to detect the presence, severity, and response to treatment of movement disorders.