MODULATION OF EPITHELIAL-CELL GROWTH BY INTRAEPITHELIAL GAMMA-DELTA T-CELLS
MODULATION OF EPITHELIAL-CELL GROWTH BY INTRAEPITHELIAL GAMMA-DELTA T-CELLS
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DOI：
10.1126/science.7973709
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发表时间：
1994-11-18
期刊：
影响因子：
56.9
通讯作者：
HAVRAN, WL
中科院分区：
文献类型：
--
作者：
BOISMENU, R;HAVRAN, WL
驻留在各种上皮细胞中的γ δ T细胞在免疫监视中所起的作用尚不清楚。这里显示，从皮肤和肠获得的活化γ δ T细胞表达上皮细胞促分裂原角质形成细胞生长因子（KGF）。相反，上皮内α β T细胞，以及所有淋巴α β和γ δ T细胞群测试，不产生KGF或促进培养的上皮细胞的生长。这些结果表明，上皮内γ δ T细胞在监视和修复受损的上皮组织中起作用。
The role played in immune surveillance by gamma delta T cells residing in various epithelia has not been clear. It is shown here that activated gamma delta T cells obtained from skin and intestine express the epithelial cell mitogen keratinocyte growth factor (KGF). In contrast, intraepithelial alpha beta T cells, as well as all lymphoid alpha beta and gamma delta T cell populations tested, did not produce KGF or promote the growth of cultured epithelial cells. These results suggest that intraepithelial gamma delta T cells function in surveillance and in repair of damaged epithelial tissues.