Responses of isolated Golgi tendon organs of cat to sinusoidal stretch.
Responses of isolated Golgi tendon organs of cat to sinusoidal stretch.
复制标题
猫离体高尔基腱器官对正弦拉伸的反应。
DOI：
10.1152/jn.1983.49.4.976
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发表时间：
1983
影响因子：
2.5
通讯作者：
Fukami,Y
中科院分区：
文献类型：
--
作者：
Wilkinson,RS;Fukami,Y
1. 从离体高尔基肌腱器官中记录了受体电位和张力对正弦拉伸的反应。反应取决于拉伸的幅度和频率以及制备的初始（静息）张力。2. 张力和受体电位在与生理肌腱应变相对应的大部分范围内都表现为拉伸幅度的幂函数。然而，对于非常小的拉伸幅度（小于8微米），可以看到更线性的响应。依赖于拉伸幅度的响应特征在所有检测频率下表现相似。3. 张力的频率依赖性较弱。其特征是随着拉伸频率的增加，响应逐渐单调增加，并且相位超前数度不变，在0.12至80 Hz的检测频率范围内没有变化。与此相反，受体电位表现出明显的频率依赖性，在1 ~ 20 Hz范围内，随着拉伸频率的增加而迅速增加，然后随着频率的进一步增加而缓慢下降。4. 制备的初始张力的变化在张力和受体电位的振幅依赖性上产生了显著的平行变化。频率响应未受显著影响。5. 通过比较张力和受体电位反应，考察了受体的机械和电特性对感觉转导过程的相对贡献。目前的结果表明，在肌腱器官中，观察到的对拉伸幅度的非线性依赖主要源于转导的机械阶段。然而，动态敏感性似乎主要归因于感觉终端膜内的离子过程。
1. Receptor potential and tension have been recorded from isolated Golgi tendon organs in response to sinusoidal stretch. Responses depended on amplitude and frequency of stretch and on the initial (resting) tension of the preparation. 2. Both tension and receptor potential behaved as power functions of stretch amplitude over most of the range corresponding to physiological tendon strains. However, for very small stretch amplitudes (less than 8 microns), a more linear response was seen. Those characteristics of responses that depended on stretch amplitude behaved similarly at all frequencies examined. 3. Frequency dependence of tension was slight. Its character, a gradual monotonic increase in response with increasing stretch frequency and a constant phase lead of a few degrees, did not change over the examined frequency range from 0.12 to 80 Hz. In contrast, receptor potential displayed a marked frequency dependence, increasing rapidly with increasing frequency of stretch in the range from approximately 1 to 20 Hz, then slowly declining as frequency was further increased. 4. Changes in initial tension of the preparation produced marked parallel changes in the amplitude dependence of tension and receptor potential. Frequency response was not significantly affected. 5. By comparing tension and receptor potential responses, the relative contributions of mechanical and electrical properties of the receptor to the sensory transduction process was examined. The present results suggest that in tendon organs the observed nonlinear dependence on amplitude of stretch originates primarily in the mechanical stage of transduction. Dynamic sensitivity, however, seems largely attributable to ionic processes within the sensory terminal membranes.