Metallomics
Metallomics
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DOI：
10.2116/analsci.highlights1907
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发表时间：
2019-07
影响因子：
1.6
通讯作者：
T. Yabutani
中科院分区：
文献类型：
--
作者：
T. Yabutani
金属组学可以定义为对细胞、细胞区室或特定组织类型中的金属进行全面分析。在大多数情况下，质谱在形态分析中起着关键作用。读者熟悉金属组学方法的相关工具和应用方面，为理解环境和生物体中金属的命运，途径和作用铺平了道路。观察细胞中金属平衡的变化是了解癌症或阿尔茨海默病等各种疾病发病机制的关键。
Metallomics can be defined as the comprehensive analysis of metals in cells, cell compartments, or a specific tissue type. In most cases, mass spectrometry plays a key role in the speciation analysis. The reader gets acquainted with relevant instrumental as well as application aspects of metallomics approaches, paving the road to understanding fate, pathway, and action of metals in environment and organisms. The observation of shifts in metal balances in the cell is a key to understand the pathogenesis of various diseases such as cancer or Alzheimer's disease.