Increased activity of serum mitochondrial isoenzyme of creatine kinase in hepatocellular carcinoma patients predominantly with recurrence
Increased activity of serum mitochondrial isoenzyme of creatine kinase in hepatocellular carcinoma patients predominantly with recurrence
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DOI：
10.1016/j.jhep.2012.03.012
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发表时间：
2012-08-01
影响因子：
25.7
通讯作者：
Ikeda, Hitoshi
中科院分区：
文献类型：
--
作者：
Soroida, Yoko;Ohkawa, Ryunosuke;Ikeda, Hitoshi
背景与目的：线粒体肌酸激酶同工酶（MtCK）在肝细胞癌（HCC）中高表达。采用一种新的免疫抑制法检测肝癌患者血清MtCK活性，并与临床相关性进行评价。（12例首次发生，135例复发）和92例非HCC患者入组。HCC患者血清MtCK活性高于非HCC患者或健康受试者。肝癌患者血清MtCK活性升高，射频消融后降低。如果预测HCC。MTCK在8.0 U/L的临界值下的敏感性为62.6%，特异性为70.7%，受试者工作曲线下面积为0.722，甲胎蛋白（AFP）为0.713，脱-γ-羧基凝血酶原（DCP）为0.764。在肝癌患者中，52.9%的AFP阳性者血清MtCK活性升高
Background & Aims: Mitochondrial isoenzyme of creatine kinase (MtCK) is reportedly highly expressed in hepatocellular carcinoma (HCC). Clinical relevance of serum MtCK activity in patients with HCC was assessed using a novel immuno-inhibition method.Methods: Among patients with cirrhosis caused by hepatitis B or C virus, 147 patients with HCC (12 with the first occurrence and 135 with recurrence) and 92 patients without HCC were enrolled.Results: Serum MtCK activity was higher in cirrhotic patients with HCC than in those without HCC or healthy subjects. Elevated serum MtCK activity in HCC patients decreased after radiofrequency ablation. In case of prediction of HCC. MtCK had a sensitivity of 62.6% and a specificity of 70.7% at a cut-off point of 8.0 U/L, with an area under the receiver operating curve of 0.722 vs. 0.713 for alpha-fetoprotein (AFP) and 0.764 for des-gamma-carboxy prothrombin (DCP). Among the HCC patients, serum MtCK activity was elevated in 52.9% individuals with serum AFP level