Expression of Glucose Transporters 1 and 3 in Metastatic and Non-Metastatic Lower Lip Squamous Cell Carcinoma
Expression of Glucose Transporters 1 and 3 in Metastatic and Non-Metastatic Lower Lip Squamous Cell Carcinoma
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DOI：
10.1590/0103-6440201300054
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发表时间：
2014-10-01
影响因子：
--
通讯作者：
Pinto, Leão Pereira
中科院分区：
文献类型：
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作者：
Demeda, Clarissa Favero;Carvalho, Cyntia Helena Pereira de;Pinto, Leão Pereira
本研究旨在探讨葡萄糖转运蛋白1（GLUT-1）和3（GLUT-3）在转移性和非转移性下唇鳞状细胞癌（LLSCC）中的免疫表达。选择20例有区域淋巴结转移的LLSCC和20例无转移的LLSCC。评估每个肿瘤核心和深部浸润前沿的染色分布和GLUT-1和GLUT-3染色百分比。大多数肿瘤（70%）在肿瘤细胞的巢、片和岛中表现出GLUT-1的外周染色，而观察到GLUT-3的主要中央染色（72.5%）。在转移性和非转移性肿瘤的深部浸润前沿和肿瘤核心观察到高百分比的GLUT-1阳性细胞（p>0.05）。GLUT-1阳性细胞的百分比在深部浸润前沿明显高于GLUT-3阳性细胞（p
This study aimed to evaluate the immunoexpression of glucose transporters 1 (GLUT-1) and 3 (GLUT-3) in metastatic and non-metastatic lower lip squamous cell carcinoma (LLSCC). Twenty LLSCCs with regional nodal metastasis and 20 LLSCCs without metastasis were selected. The distribution of staining and the percentage of GLUT-1 and GLUT-3 staining in each tumor core and at the deep invasive front were assessed. Most tumors (70%) exhibited peripheral staining for GLUT-1 in nests, sheets and islands of neoplastic cells, whereas predominantly central staining was observed for GLUT-3 (72.5%). A high percentage of GLUT-1-positive cells was observed at the deep invasive front and in the tumor core of metastatic and non-metastatic tumors (p>0.05). The percentage of GLUT-1-positive cells was much higher than that of GLUT-3-positive cells both in the deep invasive front (p