Cerebral activation in abstinent ecstasy (MDMA) users during a working memory task: a functional magnetic resonance imaging (MRI) study
Cerebral activation in abstinent ecstasy (MDMA) users during a working memory task: a functional magnetic resonance imaging (MRI) study
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DOI：
10.1016/s0926-6410(03)00075-2
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发表时间：
2003-05-01
期刊：
影响因子：
--
通讯作者：
Gouzoulis-Mayfrank, E
中科院分区：
文献类型：
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作者：
Daumann, J;Fimm, B;Gouzoulis-Mayfrank, E
在动物研究中，流行的娱乐性毒品摇头丸（3，4-亚甲二氧基甲基苯丙胺=MDMA和相关同系物）对中枢神经系统具有神经毒性。到目前为止，人类与神经毒性有关的功能缺陷的最令人信服的证据来自神经认知研究，这些研究表明摇头丸使用者的长期学习和记忆问题与剂量有关。在我们的研究中，我们使用功能性磁共振成像（fMRI）和工作记忆任务，以调查大脑激活11重，但目前禁欲MDMA用户和两个同样大小的组的中度用户和非用户。在保守的显著性水平上，工作记忆表现和皮层激活模式没有显著的组间差异。然而，对于一个更自由的统计标准，两个用户组显示出更强的激活比控制在右顶叶皮层。此外，重度使用者在额叶和颞叶区域的血氧水平依赖（BOLD）反应比中度使用者和对照组弱。我们的研究结果可能表明，微妙的改变与以前的MDMA使用的大脑功能，虽然这些组的差异的替代解释必须考虑。(C)2003 Elsevier Science B. V.保留所有权利。
The popular recreational drug ecstasy (3,4-methylenedioxymethamphetamine=MDMA and related congeners) is neurotoxic upon central serotonergic systems in animal studies. So far, the most convincing evidence for neurotoxicity-related functional deficits in humans derives from neurocognitive studies demonstrating dose-related long-term learning and memory problems in ecstasy users. In our study we used functional magnetic resonance imaging (fMRI) and a working memory task to investigate cerebral activation in eleven heavy, but currently abstinent MDMA users and two equally sized groups of moderate users and non-users. There were no significant group differences in working memory performance and no differences in cortical activation patterns for a conservative level of significance. However, for a more liberal statistical criterion, both user groups showed stronger activations than controls in right parietal cortex. Furthermore, heavy users had a weaker blood oxygenation level-dependent (BOLD) response than moderate users and controls in frontal and temporal areas. Our results may indicate subtle altered brain functioning associated with prior MDMA use, although alternative interpretations of these group differences must be considered. (C) 2003 Elsevier Science B.V. All rights reserved.